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Sirpiglenastat  (Synonyms: DRP-104)

Cat. No.: HY-132832 Purity: 98.06%
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Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.

For research use only. We do not sell to patients.

Sirpiglenastat Chemical Structure

Sirpiglenastat Chemical Structure

CAS No. : 2079939-05-0

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1 mg USD 380 In-stock
5 mg USD 1140 In-stock
10 mg USD 2000 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Sirpiglenastat Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response[1][2].

In Vitro

Sirpiglenastat (DRP-104) treatment shows broad immune cell modulation effects including increased T, NK, and macrophages. Sirpiglenastat decreases pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sirpiglenastat Related Antibodies
In Vivo

CT26 bearing mice treated with Sirpiglenastat (DRP-104) (0.5 mg/kg; s.c.; once a day; for 5 days) shows tumor growth inhibition at day 12 of 90%. Median survival days are 36 days[1].
Sirpiglenastat (0.5 mg/kg; s.c) treatment significantly inhibits tumor growth in the H22 model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 bearing mice[1]
Dosage: 0.5 mg/kg
Administration: s.c.; once a day; for 5 days
Result: Showed tumor growth inhibition in mice.
Clinical Trial
Molecular Weight

441.48

Formula

C22H27N5O5
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

CC(C)OC([C@H](CCC(C=[N+]=[N-])=O)NC([C@@H](NC(C)=O)CC1=CNC2=CC=CC=C12)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (226.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2651 mL 11.3255 mL 22.6511 mL
5 mM 0.4530 mL 2.2651 mL 4.5302 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2651 mL 11.3255 mL 22.6511 mL 56.6277 mL
5 mM 0.4530 mL 2.2651 mL 4.5302 mL 11.3255 mL
10 mM 0.2265 mL 1.1326 mL 2.2651 mL 5.6628 mL
15 mM 0.1510 mL 0.7550 mL 1.5101 mL 3.7752 mL
20 mM 0.1133 mL 0.5663 mL 1.1326 mL 2.8314 mL
25 mM 0.0906 mL 0.4530 mL 0.9060 mL 2.2651 mL
30 mM 0.0755 mL 0.3775 mL 0.7550 mL 1.8876 mL
40 mM 0.0566 mL 0.2831 mL 0.5663 mL 1.4157 mL
50 mM 0.0453 mL 0.2265 mL 0.4530 mL 1.1326 mL
60 mM 0.0378 mL 0.1888 mL 0.3775 mL 0.9438 mL
80 mM 0.0283 mL 0.1416 mL 0.2831 mL 0.7078 mL
100 mM 0.0227 mL 0.1133 mL 0.2265 mL 0.5663 mL
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Sirpiglenastat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sirpiglenastat2079939-05-0DRP-104DRP104DRP 104OthersanticancerimmunecheckpointVEGFIL-8Inhibitorinhibitorinhibit

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