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Sirpiglenastat (Synonyms: DRP-104)

Cat. No.: HY-132832
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Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.

For research use only. We do not sell to patients.

Sirpiglenastat Chemical Structure

Sirpiglenastat Chemical Structure

CAS No. : 2079939-05-0

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Description

Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response[1][2].

In Vitro

Sirpiglenastat (DRP-104) treatment shows broad immune cell modulation effects including increased T, NK, and macrophages. Sirpiglenastat decreases pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CT26 bearing mice treated with Sirpiglenastat (DRP-104) (0.5 mg/kg; s.c.; once a day; for 5 days) shows tumor growth inhibition at day 12 of 90%. Median survival days are 36 days[1].
Sirpiglenastat (0.5 mg/kg; s.c) treatment significantly inhibits tumor growth in the H22 model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 bearing mice[1]
Dosage: 0.5 mg/kg
Administration: s.c.; once a day; for 5 days
Result: Showed tumor growth inhibition in mice.
Molecular Weight

441.48

Formula

C₂₂H₂₇N₅O₅

CAS No.
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Sirpiglenastat
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