157-03-9
Chemical Structure
6-Diazo-5-oxo-L-nor-Leucine
Synonym(s): L-6-Diazo-5-oxonorleucine; DON
- CAS No.: 157-03-9
- Formula:C6H9N3O3
- Molecular Weight:171.15
IUPAC Name: (S)-2-amino-6-diazo-5-oxohexanoic acid
InChIKey: YCWQAMGASJSUIP-YFKPBYRVSA-N
SMILES: N[C@@H](CCC(C=[N+]=[N-])=O)C(O)=O
Biological Activity: 6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
6-Diazo-5-oxo-L-nor-Leucine | 99.98% | 6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
6-Diazo-5-oxo-L-nor-Leucine (Standard) | ≥98% | 6-Diazo-5-oxo-L-nor-Leucine (Standard) is the analytical standard of 6-Diazo-5-oxo-L-nor-Leucine. This product is intended for research and analytical applications. 6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 1.00
HY-W1420256-Diazo-5-oxo-D-norleucine -
Similarity Score 0.92
HY-1775165-Diazo-4-oxonorvaline -
Similarity Score 0.82
HY-105723Duazomycin -
Similarity Score 0.81
HY-100805S1D-Glutamic acid-13C5,15N -
Similarity Score 0.81
HY-100805S2D-Glutamic acid-13C5 -
Similarity Score 0.81
HY-14608SL-Glutamic acid-13C -
Similarity Score 0.81
HY-14608S10L-Glutamic acid-13C2 -
Similarity Score 0.81
HY-14608S2L-Glutamic acid-15N -
Similarity Score 0.81
HY-14608S3L-Glutamic acid-13C5,15N -
Explore the MedChemAI to find more analogs
References
- [1]. Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82. [Content Brief]
- [2]. Sharma NS, et al. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2019 Oct 15. [Content Brief]
- [3]. DeWald H A, et al. 6-diazo-5-oxo-l-norleucine, a new tumor-inhibitory substance. 1a preparation of l-, d-and dl-forms1b. Journal of the American Chemical Society, 1958, 80(15): 3941-3945.
