2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Endogenous Metabolite iGluR Ferroptosis Apoptosis
  4. L-Glutamic acid-15N

L-Glutamic acid-15N is the 15N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals[1].

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L-Glutamic acid-<sup>15</sup>N Chemical Structure

L-Glutamic acid-15N Chemical Structure

CAS No. : 21160-87-2

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Glutamic acid-15N:

L-Glutamic acid-15N Related Antibodies

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Description

L-Glutamic acid-15N is the 15N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals[1].

IC50 & Target

NMDA Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Glutamic acid-15N Related Antibodies
Molecular Weight

148.12

Formula

C5H915NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CC[C@H]([15NH2])C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (33.76 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7513 mL 33.7564 mL 67.5128 mL
5 mM 1.3503 mL 6.7513 mL 13.5026 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.7513 mL 33.7564 mL 67.5128 mL 168.7821 mL
5 mM 1.3503 mL 6.7513 mL 13.5026 mL 33.7564 mL
10 mM 0.6751 mL 3.3756 mL 6.7513 mL 16.8782 mL
15 mM 0.4501 mL 2.2504 mL 4.5009 mL 11.2521 mL
20 mM 0.3376 mL 1.6878 mL 3.3756 mL 8.4391 mL
25 mM 0.2701 mL 1.3503 mL 2.7005 mL 6.7513 mL
30 mM 0.2250 mL 1.1252 mL 2.2504 mL 5.6261 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Glutamic acid-15N Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutamic acid-15N21160-87-2Endogenous MetaboliteiGluRFerroptosisApoptosisIonotropic glutamate receptorsInhibitorinhibitorinhibit

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