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Mn2

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49

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5

Fluorescent Dye

17

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2

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Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0155
    Zinpyr-1
    4 Publications Verification

    Fluorescent Dye Others
    Zinpyr-1 is a zinc-responsive fluorescent indicator and a membrane-permeable metal-binding probe. Zinpyr-1 forms a complex with Mn 2+ ions and generates a fluorescence turn-on signal. Zinpyr-1 binds to free zinc ions in serum, enabling quantitative detection of free zinc concentration. Zinpyr-1 produces fluorescence signals reflecting the relative zinc concentration in plant root cells, localizes to specific layers of plant root cells, and can be used to support analyses related to plant zinc transporter mutations and homeostasis [2] .
    Zinpyr-1
  • HY-NP164

    Con A-HRP

    Fluorescent Dye Cancer
    Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins [2].


    Concanavalin A-HRP
  • HY-NP009

    Bacterial Infection Neurological Disease
    α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca 2+, Mg 2+, Mn 2+, Na +, K + and Zn 2+ ions; among these, Ca 2+ binding enhances protein stability, while Zn 2+ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions [2] .
    α-Lactalbumin
  • HY-132188

    Endogenous Metabolite Others
    Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization [2].
    Manganese peroxidase
  • HY-E70373

    Biochemical Assay Reagents Others
    λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn 2+. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase
    λ Protein phosphatase
  • HY-164220

    Phosphatase Bacterial Infection
    PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis .
    PPM1A-IN-1
  • HY-173084

    Phosphatase MDM-2/p53 Cancer
    BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC50 of 5 nM. BRD6257 activates p53 signaling pathway with an EC50 of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC50=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes .
    BRD6257
  • HY-P2936

    Phospholipase Cardiovascular Disease Infection
    Sphingomyelin phosphodiesterase, Streptomyces sp. is a sphingomyelin phosphodiesterase derived from the genus Streptomyces, which cleaves the phosphodiester bond of sphingomyelin. Sphingomyelin phosphodiesterase, Streptomyces sp. catalyzes the hydrolysis of sphingomyelin in micelles, synthetic substrates, erythrocyte ghost membranes and liposomes, as well as the hydrolysis of the substrate HNP. In the presence of Mg 2+ or Mn 2+ , Sphingomyelin phosphodiesterase, Streptomyces sp. induces hemolysis of bovine erythrocytes through the hydrolysis of membrane sphingomyelin [2].
    Sphingomyelin phosphodiesterase, Streptomyces sp.
  • HY-P1188

    Integrin Cancer
    LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn 2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity [2].
    LDV-FITC
  • HY-W250119
    Calcium disodium edetate hydrate
    20+ Cited Publications

    EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate

    Biochemical Assay Reagents Fungal Mitochondrial Metabolism Infection
    Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn 2+, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold [2].
    Calcium disodium edetate hydrate
  • HY-Y1422E

    Biochemical Assay Reagents Lipase Others
    Lipase, Aspergillus niger (Immobilized) is an immobilized triacylglycerol acyl hydrolase and biocatalyst. Lipase, Aspergillus niger (Immobilized) broadly catalyzes the hydrolysis of glycerol-long-chain fatty acid esters, exhibits positional selectivity for the 1,3-positions of glycerol, but shows low hydrolysis efficiency for castor oil. Lipase, Aspergillus niger (Immobilized) displays optimal activity at 45°C and pH 7.0, and remains stable at temperatures up to 60°C and over a broad pH range of 2.0-9.0. Lipase, Aspergillus niger (Immobilized) is activated by Ca 2+ and Mg 2+, but inhibited by Mn 2+, Fe 2+ and Zn 2+ [2] .
    Lipase,Aspergillusniger (Immobilized)
  • HY-W241345

    Radionuclide-Drug Conjugates (RDCs) Cancer
    DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
    DOTA-bis(tert-butyl)ester
  • HY-NP164B

    Con A-AF488

    Fluorescent Dye Cancer
    Concanavalin A-AF488 (Con A-AF488) is an AF488-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF488
  • HY-E71136

    Biochemical Assay Reagents Others
    (S)-β-Bisabolene synthase (EC 4.2.3.55) requires Mg2+ or Mn2+ for activity.
    (S)-β-Bisabolene synthase
  • HY-E71065

    Biochemical Assay Reagents Others
    (2Z,6E)-Farnesyl diphosphate synthaserequires Mg2+ or Mn2+ for activity.
    (2Z,6E)-Farnesyl diphosphate synthase
  • HY-E71302

    Biochemical Assay Reagents Others
    β-Galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,3-acetylglucosaminyltransferase (EC 2.4.1.163) requires Mn2+.
    β-Galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide β-1,3-acetylglucosaminyltransferase
  • HY-E71193

    Biochemical Assay Reagents Others
    15-cis-Phytoene synthase (EC 2.5.1.32) requires Mn2+ for activity. 15-cis-Phytoene synthase (EC 2.5.1.32) produces 15-cis-Phytoene.
    15-cis-Phytoene synthase
  • HY-E71101

    Biochemical Assay Reagents Others
    (R)-Limonene synthase (EC 4.2.3.20) requires divalent metal ions (preferably Mn2+) for catalysis. (R)-Limonene synthase (EC 4.2.3.20) is found in plants of the genera Citrus, Carum, and Anethum.
    (R)-Limonene synthase
  • HY-E71283

    Biochemical Assay Reagents Others
    β-Copaene synthase (EC 4.2.3.127) forms (+)-Δ-cadinene, β-Cubebene, (+)-sativene and traces of several other sequiterpenoids. β-Copaene is formed in the presence of Mg2+ but not Mn2+.
    β-Copaene synthase
  • HY-E71073

    Biochemical Assay Reagents Others
    (4S)-Limonene synthaseis a recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.
    (4S)-Limonene synthase
  • HY-E71172

    Biochemical Assay Reagents Others
    1,8-Cineole synthase (EC 4.2.3.108) requires either Mn2+ or Zn2+. 1,8-Cineole is the major product of 1,8-Cineole synthase (EC 4.2.3.108).
    1,8-Cineole synthase
  • HY-E71134

    Biochemical Assay Reagents Others
    (S)-Ureidoglycine aminohydrolase (EC 3.5.3.26) binds to Mn2+. (S)-Ureidoglycine aminohydrolase (EC 3.5.3.26) , found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum.
    (S)-Ureidoglycine aminohydrolase
  • HY-E71326

    Biochemical Assay Reagents Others
    β-Ribofuranosylphenol 5'-phosphate synthase (EC 2.4.2.54) is involved in biosynthesis of tetrahydromethanopterin in archaea. It was initially thought to use 4-aminobenzoate as a substrate, but was later shown to utilize 4-hydroxybenzoate. The activity is dependent on Mg2+ or Mn2+.
    β-Ribofuranosylphenol 5'-phosphate synthase
  • HY-E71097

    Biochemical Assay Reagents Others
    (R)-Citramalyl-CoA lyase (EC 4.1.3.46) requires Mn2+ ions for activity. (R)-Citramalyl-CoA lyase (EC 4.1.3.46) , purified from the bacterium Chloroflexus aurantiacus, has no activity with (3S)-citramalyl-CoA.
    (R)-Citramalyl-CoA lyase
  • HY-E71252

    Biochemical Assay Reagents Others
    α-Seco-amyrin synthase (EC 5.4.99.52) requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost.
    α-Terpinene synthase
  • HY-E71074

    Biochemical Assay Reagents Others
    (4S)-β-Phellandrene synthase (geranyl-diphosphate-cyclizing) (EC 4.2.3.52) requires Mn2+. Mg2+ is not effective. (4S)-β-Phellandrene synthase (geranyl-diphosphate-cyclizing) (EC 4.2.3.52) n involves a 1,3-hydride shift.
    (4S)-β-Phellandrene synthase geranyl-diphosphate-cyclizing
  • HY-E71347

    Biochemical Assay Reagents Others
    γ-Terpinene synthase (EC 4.2.3.114) requires Mg2+. Mn2+ less effective. The reaction involves a 1,2-hydride shift. The 5-pro-S hydrogen of geranyl diphosphate is lost. Traces of several other monoterpenoids are formed in addition to γ-Terpinene.
    γ-Terpinene synthase
  • HY-132188A

    Biochemical Assay Reagents Metabolic Disease
    Manganese Peroxidase, Nematoloma frowardii (EC 1.11.1.13) is a hemecontaining glycoprotein that is produced by ligninolytic basidiomycetes. It requires hydrogen peroxide as an oxidant. Manganese Peroxidase, Nematoloma frowardii (EC 1.11.1.13) oxidizes Mn2+ to Mn3+. Mn3+ oxidizes phenolic rings to phenoxy radicals which results in the decomposition of various compounds.
    Manganese Peroxidase, Nematoloma frowardii
  • HY-E71068

    Biochemical Assay Reagents Others
    (3S)-Malyl-CoA thioesterase (EC 3.1.2.30) is stimulated by Mg2+ or Mn2+. (3S)-Malyl-CoA thioesterase (EC 3.1.2.30) has no activity with (2R,3S)-2-methylmalyl-CoA or other CoA esters.
    (3S)-Malyl-CoA thioesterase
  • HY-E71168

    Biochemical Assay Reagents Others
    1,6-α-D-Mannosidase (EC 3.2.1.163) is specific for (1→6)-linked mannobiose and has no activity towards any other linkages, or towards p-nitrophenyl-α-D-mannopyranoside or baker's yeast mannan. It is strongly inhibited by Mn2+ but does not require Ca2+ or any other metal cofactor for activity.
    1,6-α-D-Mannosidase
  • HY-174849

    DNA/RNA Synthesis Cancer
    TdT-IN-1 (Compound 8c) is a selective and non-nucleoside terminal deoxynucleotidyl transferase (TdT) inhibitor with IC50 s of 0.11 and 0.19 μM for Mg 2+ and Mn 2+. TdT-IN-1 can be used for leukaemias and skin cancer research .
    TdT-IN-1
  • HY-NP164K

    Con A-AF568

    Fluorescent Dye Cancer
    Concanavalin A-AF568 (Con A-AF546) is an AF568-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF568
  • HY-NP164M

    Con A-AF680

    Fluorescent Dye Cancer
    Concanavalin A-AF680 (Con A-AF680) is an AF680-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF680
  • HY-NP164D

    Con A-AF405

    Fluorescent Dye Cancer
    Concanavalin A-AF405 (Con A-AF405) is an AF405-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF405
  • HY-NP164I

    Con A-AF546

    Fluorescent Dye Cancer
    Concanavalin A-AF546 (Con A-AF546) is an AF546-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF546
  • HY-NP164E

    Con A-AF430

    Fluorescent Dye Cancer
    Concanavalin A-AF430 (Con A-AF430) is an AF430-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF430
  • HY-NP164O

    Con A-Cy5

    Fluorescent Dye Cancer
    Concanavalin A-Cy5 (Con A-Cy5) is a Cy5 (HY-D0821)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 630/670 nm) .
    Concanavalin A-Cy5
  • HY-P1188A

    Integrin Cancer
    LDV-FITC TFA, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC TFA binds to the α4β1 integrin with high affinity (Kd: 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn 2+ respectively). LDV-FITC TFA can be used to detect α4β1 integrin affinity [2].
    LDV-FITC TFA
  • HY-D3243

    Fluorescent Dye Others
    Mn1 (M1) is a BODIPY-based Mn 2+-selective "turn-on" Fluorescent sensor and fluorescence modulator. In the absence of Mn 2+, Mn1 undergoes fluorescence quenching via photoinduced electron transfer; binding to Mn 2+ inhibits this mechanism, thereby generating a fluorescence "turn-on" response. Mn1 exhibits Mn 2+-specific cellular fluorescence response .
    Mn1
  • HY-D3244

    Fluorescent Dye Others
    RDDB is a rhodamine-based turn-on fluorescent and colorimetric chemosensor selective for Mn 2+, with a limit of detection of 5×10 -8 M (excitation wavelength: 480-550 nm; fluorescence signal collection range: >590 nm). In the presence of Mn 2+, RDDB undergoes a spirolactam ring-opening reaction of its rhodamine hydrazide moiety, resulting in turn-on fluorescence and a color change. RDDB can be used for intracellular Mn 2+ imaging .
    RDDB
  • HY-D3030

    Fluorescent Dye Cancer
    Concanavalin A-FITC is a FITC (HY-66019)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 488/525 nm) .
    Concanavalin A-FITC
  • HY-NP164L

    Con A-AF647

    Fluorescent Dye Cancer
    Concanavalin A-AF647 (Con A-AF647) is an AF647-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF647
  • HY-NP164J

    Con A-AF555

    Fluorescent Dye Cancer
    Concanavalin A-AF555 (Con A-AF555) is an AF555-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF555
  • HY-D3031

    Fluorescent Dye Cancer
    Concanavalin A-TRITC is a TRITC (HY-D0791)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 544/570 nm) .
    Concanavalin A-TRITC
  • HY-NP164C

    Con A-AF350

    Fluorescent Dye Cancer
    Concanavalin A-AF350 (Con A-AF350) is an AF350-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF350
  • HY-NP164H

    Con A-AF532

    Fluorescent Dye Cancer
    Concanavalin A-AF532 (Con A-AF532) is an AF532-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-AF532
  • HY-NP164A

    Con A-Cy5.5

    Fluorescent Dye Cancer
    Concanavalin A-Cy5.5 (Con A-Cy5.5) is a Cy5.5 (HY-D0924)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .
    Concanavalin A-Cy5.5
  • HY-NP164N

    Con A-Cy3

    Fluorescent Dye Cancer
    Concanavalin A-Cy3 (Con A-Cy3) is a Cy5 (HY-D0822)-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins (Ex/Em = 554/568 nm) .
    Concanavalin A-Cy3
  • HY-182419

    MetAP Cancer
    A-849519 is a reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 19 nM. A-849519 binds to the active site of the Mn 2+ form of human MetAP-2, where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2 as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma [2].
    A-849519

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