Sphingomyelin phosphodiesterase, Streptomyces sp. 

Sphingomyelin phosphodiesterase, Streptomyces sp. is a sphingomyelin phosphodiesterase derived from the genus Streptomyces, which cleaves the phosphodiester bond of sphingomyelin. Sphingomyelin phosphodiesterase, Streptomyces sp. catalyzes the hydrolysis of sphingomyelin in micelles, synthetic substrates, erythrocyte ghost membranes and liposomes, as well as the hydrolysis of the substrate HNP. In the presence of Mg²⁺ or Mn²⁺ , Sphingomyelin phosphodiesterase, Streptomyces sp. induces hemolysis of bovine erythrocytes through the hydrolysis of membrane sphingomyelin^[1][2].

Sphingomyelin phosphodiesterase from *Streptomyces* sp. (15 munits enzyme; 10 min) induces 80%-100% hemolysis and complete SM hydrolysis in intact bovine erythrocytes^[2].
Sphingomyelin phosphodiesterase from *Streptomyces* sp. exhibits hydrolytic activity against HNP, with an activity of 0.0026 μmol/min·units^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9031-54-3

Solid

White to off-white

[Sphingomyelin phosphodiesterase, Streptomyces sp.]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sugimori D, et al. Extracellular production of a sphingomyelinase from Streptomyces griseocarneus using Streptomyces lividans. Biotechnol Lett. 2011;33(4):727-731.  [Content Brief]

  [2]. Matsuyama H, et al. Alteration in reactivity of sphingomyelinase from Streptomyces sp. modified with a polyethylene glycol derivative. Biol Pharm Bull. 1993;16(2):107-111.  [Content Brief]