Calcium disodium edetate hydrate
Based on 27 publication(s) in Google Scholar
Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn2+, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 23411-34-9
- Formula: C10H12CaN2O8.xH2O.2Na
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications Citing Use of MedChemExpress (MCE) Calcium disodium edetate hydrate
More- Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]
- J Extracell Vesicles. 2025 Sep;14(9):e70162. [Abstract]
- Bone Res. 2025 Mar 3;13(1):30. [Abstract]
- Neuron. 2025 Jul 29:S0896-6273(25)00509-4. [Abstract]
- J Nanobiotechnology. 2025 Mar 6;23(1):175. [Abstract]
- Nucleic Acids Res. 2024 Dec 11;52(22):14112-14132. [Abstract]
- Adv Sci (Weinh). 2026 May;13(25):e15362. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(13):e2415229. [Abstract]
- Adv Sci (Weinh). 2025 Feb;12(6):e2411261. [Abstract]
- Adv Sci (Weinh). 2023 Feb;10(4):e2204998. [Abstract]
- Int J Biol Macromol. 2026 Jan;335(Pt 2):149182. [Abstract]
- Int J Biol Macromol. 2025 Jun;311(Pt 3):144068. [Abstract]
- Int J Biol Macromol. 2023 Jan 15:225:1182-1192. [Abstract]
- EMBO Mol Med. 2025 Oct 15. [Abstract]
- Colloids Surf B Biointerfaces. 2024 Feb:234:113680. [Abstract]
- Molecules. 2024 Jul 30;29(15):3590. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2026 Jan 24;1872(4):168169. [Abstract]
- Ann Med. 2025 Dec;57(1):2548045. [Abstract]
- Food Qual Saf. 2025 Aug 4.
- iScience. 2026 Jun 1;29(6):116200. [Abstract]
- J Orthop Surg Res. 2025 Apr 22;20(1):403. [Abstract]
- J Diabetes Investig. 2026 Jun 8. [Abstract]
- Breast Cancer (Dove Med Press). 2025 Dec 20:17:1265-1278. [Abstract]
- Cell Immunol. 2024 Jan-Feb:395-396:104781. [Abstract]
- BMC Med Genomics. 2025 Aug 9;18(1):128. [Abstract]
- Biosci Biotechnol Biochem. 2026 Jun 23;90(7):877-885. [Abstract]
- bioRxiv. 2023 Sep 8.
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IHC
Biological Activity
Calcium disodium edetate hydrate (3.125-50 mmol L−1) completely inhibits hyphal growth of Penicillium digitatum strain P44 in vitro, with an MIC/MFC of 50 mmol L−1[2].
Calcium disodium edetate hydrate (12.5-50 mmol L-1; 8-12 h) dose-dependently delays and inhibits conidial germination of Penicillium digitatum strain P44 in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 23411-34-9
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Appearance Solid
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Formula C10H12CaN2O8.xH2O.2Na
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Color White to off-white
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SMILES
O=C1[O-][Ca+2]([N]2(C1)CC3=O)([O-]3)([O-]C4=O)([O-]5)[N](C4)(CC2)CC5=O.[Na+].[x].[Na+].O
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Synonyms
EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (27)
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Journal Impact Factor
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Most Recent
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Nat Immunol
Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]2025 Oct;26(10):1660-1672. PMID: 40954252
Calcium disodium edetate hydrate purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]
Representative images of CHMP4–GFP puncta (arrowheads; left) and percentage of CHMP4 speckle+ (top right) or Annexin V+ (bottom right) cells in BMDMs incubated with PBS, 15 µM SK56, 2 mM EDTA or EDTA + SK56 at 2 h after the addition of 1 μg/ml LPS + 10 μM nigericin; scale bar, 50 µm; n = 5 repeats
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J Extracell Vesicles
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect. [Abstract]2025 Sep;14(9):e70162. PMID: 40919882 -
Bone Res
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]2025 Mar 3;13(1):30. PMID: 40025004 -
Neuron
Social interaction in mice suppresses breast cancer progression via a corticoamygdala neural circuit. [Abstract]2025 Jul 29:S0896-6273(25)00509-4. PMID: 40752486 -
J Nanobiotechnology
2025 Mar 6;23(1):175. PMID: 40050923 -
Nucleic Acids Res
2024 Dec 11;52(22):14112-14132. PMID: 39673265 -
Adv Sci (Weinh)
Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging. [Abstract]2026 May;13(25):e15362. PMID: 41747076 -
Adv Sci (Weinh)
A Novel tRF, HCETSR, Derived From tRNA-Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1-catenin Complex Axis. [Abstract]2025 Apr;12(13):e2415229. PMID: 39921434 -
Adv Sci (Weinh)
Hybrid Cell Membrane-Engineered Nanocarrier for Triple-Action Strategy to Address Pseudomonas aeruginosa Infection. [Abstract]2025 Feb;12(6):e2411261. PMID: 39721013 -
Adv Sci (Weinh)
Regulatory Fibroblast-Like Synoviocytes Cell Membrane Coated Nanoparticles: A Novel Targeted Therapy for Rheumatoid Arthritis. [Abstract]2023 Feb;10(4):e2204998. PMID: 36509660 -
Int J Biol Macromol
Targeting glutaryl-CoA dehydrogenase-driven acetyl coenzyme A acetyltransferase 2 crotonylation dysregulates cholesterol metabolism in pancreatic cancer cells. [Abstract]2026 Jan;335(Pt 2):149182. PMID: 41285334 -
Int J Biol Macromol
FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]2025 Jun;311(Pt 3):144068. PMID: 40345291 -
Int J Biol Macromol
pH-responsive magnetic Fe3O4/carboxymethyl chitosan/aminated lignosulfonate nanoparticles with uniform size for targeted drug loading. [Abstract]2023 Jan 15:225:1182-1192. PMID: 36423809 -
EMBO Mol Med
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy. [Abstract]2025 Oct 15. PMID: 41094045 -
Colloids Surf B Biointerfaces
Platelet membrane-derived biomimetic microbubbles with enhanced targeting ability for the early detection of myocardial ischemia-reperfusion injury. [Abstract]2024 Feb:234:113680. PMID: 38101143 -
Molecules
Enhancing Functional Properties and Protein Structure of Almond Protein Isolate Using High-Power Ultrasound Treatment. [Abstract]2024 Jul 30;29(15):3590. PMID: 39124994 -
Biochim Biophys Acta Mol Basis Dis
Goosecoid promotes hepatic stellate cell epithelial-mesenchymal transition via transcriptional activation of serum- and glucocorticoid-induced protein kinase 1 in liver fibrosis. [Abstract]2026 Jan 24;1872(4):168169. PMID: 41581345 -
Ann Med
Multi-omics analysis and validation of autophagy-related diagnostic biomarker in osteoarthritis. [Abstract]2025 Dec;57(1):2548045. PMID: 40828304 -
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iScience
Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids. [Abstract]2026 Jun 1;29(6):116200. PMID: 42256278 -
J Orthop Surg Res
Epimedin B protects against bone loss and inflammation in diabetic osteoporosis rats by regulating OPG/RANKL pathway. [Abstract]2025 Apr 22;20(1):403. PMID: 40264188 -
J Diabetes Investig
Hypoxia-preconditioned adipose-derived mesenchymal stem cells-derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5-mediated inactivation of TLR4/NF-κB/NLRP3 inflammatory signaling. [Abstract]2026 Jun 8. PMID: 42257551 -
Breast Cancer (Dove Med Press)
Dexmedetomidine Suppresses Mitochondrial Autophagy and Apoptosis While Promoting Proliferation in Breast Cancer Cells in vitro via PI3K/AKT Signaling. [Abstract]2025 Dec 20:17:1265-1278. PMID: 41466772 -
Cell Immunol
Dexamethasone alleviates pulmonary sarcoidosis by regulating the TGF-β/Smad3 signaling to promote Th17/Treg cell rebalance. [Abstract]2024 Jan-Feb:395-396:104781. PMID: 38159414 -
BMC Med Genomics
Arsenic sulfide alleviates the progression of liver cancer malignancy by inhibiting the expression of TLCD1 in mice. [Abstract]2025 Aug 9;18(1):128. PMID: 40783540 -
Biosci Biotechnol Biochem
Effect of pirfenidone on the regulation of lymph angiogenesis by PLK1 signaling to inhibit metastasis of lung cancer in vivo. [Abstract]2026 Jun 23;90(7):877-885. PMID: 42012458 -
Solvent & Solubility
H2O : ≥ 125 mg/mL
* "≥" means soluble, but saturation unknown.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- Calcium disodium edetate
- 23411-34-9
- EDTA disodium calcium salt
- Ethylenediaminetetraacetic acid disodium calcium salt
- Biochemical Assay Reagents
- Fungal
- Mitochondrial Metabolism
- lead poisoning
- calcium
- magnesium
- mitochondria
- iron
- glycolytic pyruvate synthesis
- glomerular filtration
- zinc
- Penicillium digitatum
- citrus green mold
- Inhibitor
- inhibitor
- inhibit