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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
O-GlcNAc transferase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "O-GlcNAc transferase" in MCE Product Catalog:
51
51 Publications Verification
Target:
Research Areas:
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
32
32 Cited Publications
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OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
8
8 Cited Publications
Synonyms: UDP-α-D-N-Acetylglucosamine disodium
Target:
Research Areas:
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).
Cat. No.: HY-N3677
CAS No.: 14351-29-2
Target:
Cat. No.: HY-149552
CAS No.: 67561-97-1
Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .
Cat. No.: HY-W039939
CAS No.: 56883-39-7
Synonyms: 2-ADG, 98%
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Research Areas:
OGT-IN-1 (Compound 5) is a potent OGT inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC50s of 27 and 10 μM, respectively .
Cat. No.: HY-112174S
Purity: 96.99%
Synonyms: UDP-α-D-N-Acetylglucosamine-13C disodium
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Research Areas:
(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
Cat. No.: HY-134902
CAS No.: 537039-67-1
Synonyms: UDP-α-6N3-glucose; 6-Azidoglucose-UDP
Research Areas:
UDP-6-azido-6-Deoxy-D-Glc (UDP-α-6N3-glucose; 6-Azidoglucose-UDP) is a UDP-sugar donor . UDP-6-azido-6-Deoxy-D-Glc is used for the selective labeling of 5-hmC in genomic DNA. UDP-6-azido-6-Deoxy-D-Glc enables glyco-diversification modification of saponin intermediates and click chemistry-based derivatization .
Cat. No.: HY-W477597
CAS No.: 1349070-58-1
BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT) with an IC50 of <10 µM. BZX2 is cell-permeable but exhibits multiple off-target effects .
Cat. No.: HY-119738R
CAS No.: 1681056-61-0
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Research Areas:
OSMI-1 (Standard) is the analytical standard of OSMI-1 (HY-119738). This product is intended for research and analytical applications. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
Cat. No.: HY-P87524
Synonyms: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT
Cat. No.: HY-134902A
Synonyms: UDP-α-6N3-glucose disodium; 6-Azidoglucose-UDP disodium
Research Areas:
UDP-6-azido-6-Deoxy-D-Glc disodium (UDP-α-6N3-glucose; 6-Azidoglucose-UDP disodium) is a UDP-sugar donor . UDP-6-azido-6-Deoxy-D-Glc disodium is used for the selective labeling of 5-hmC in genomic DNA. UDP-6-azido-6-Deoxy-D-Glc disodium enables glyco-diversification modification of saponin intermediates and click chemistry-based derivatization .
Cat. No.: HY-W699962
CAS No.: 137766-83-7
Target:
Research Areas:
Ac4GlcNAcF3 is a cell-permeable glycomimetic that can be recognized and utilized by OGT and is resistant to hydrolysis by OGA. GlcNAcF3, the active metabolite of Ac4GlcNAcF3, can be recognized by OGT as a substrate for peptide modification. Ac4GlcNAcF3 upregulates the level of cellular O-GlcNAc modification. Ac4GlcNAcF3 can be used in studies related to glycosylation regulation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
