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PP2A activator

" in MedChemExpress (MCE) Product Catalog:

標的別:	Akt (1) Apoptosis (4) Autophagy (2) c-Myc (1) CDK (1) Endogenous Metabolite (4) ERK (1) GSK-3 (1) Isotope-Labeled Compounds (1) JNK (1) MASTL (1) Mitochondrial Metabolism (1) mTOR (1) p38 MAPK (1) Phosphatase (15) PKC (4) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Survivin (1) YAP (1)
研究分野別:	Cancer (13) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)

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Targets Recommended: Calcineurin

製品番号	製品名	Target	研究分野	構造式

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator .

HY-101180

C2 Ceramide 2 Publications Verification Ceramide 2	Phosphatase Mitochondrial Metabolism Apoptosis Autophagy	Metabolic Disease Endocrinology
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates *PP2A* and *ceramide-activated* protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III**. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .

HY-112929

DT-061 Maximum Cited Publications 19 Publications Verification	Phosphatase	Cancer
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis .

HY-120272

SMAP-2 1 Publications Verification DT-1154	Phosphatase	Cancer
SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity .

HY-137552

MKI-1 1 Publications Verification MASTL Kinase Inhibitor-1	MASTL	Cancer
MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC₅₀ of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer .

HY-101047S

D-erythro-Sphingosine-d7 1 Publications Verification Erythrosphingosine-d₇; erythro-C18-Sphingosine-d₇; trans-4-Sphingenine-d₇	PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-156420

ATUX-1215	Phosphatase Apoptosis	Inflammation/Immunology Cancer
ATUX-1215 is an activator of protein phosphatase 2A (PP2A). ATUX-1215 reduced the phosphorylation of ERK, p38, JNK, and Akt and the secretion of IL-12p70, GM-CSF, and IL1α in Bleomycin hydrochloride (HY-17565A)-treated animals. ATUX-1215 can slow the progression of lung fibrosis .

HY-131443

TRC-766 DBK-766	Phosphatase	Others
TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase .

HY-163828

PPA24	Apoptosis Phosphatase c-Myc GSK-3 ERK Reactive Oxygen Species (ROS)	Cancer
PPA24 is a PP2A activator with a K_D of 8.465 μM for PP2ACα. PPA24 induces cancer cell death via apoptosis. PP2ACα induces ROS generation and decreases the level of c-Myc expression. PPA24 can be used to study colorectal cancer (CRC), Folinic acid (HY-17556), 5-Fluorouracil (HY-90006), and Oxaliplatin (HY-17371) (FOLFOX)-resistant CRC, and melanoma cancer .

HY-125953

Ceramide (Egg) Ceramide (Egg, Chicken)	JNK p38 MAPK Phosphatase Akt Survivin CDK mTOR Apoptosis Autophagy Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Ceramide (Egg) (Ceramide (Egg, Chicken)) is a ceramide from chicken. Ceramide (Egg) is a sphingomyelin signaling pathway second messenger. Ceramide (Egg) activates *PP2A, JNK, p38 MAPK, CAPK, ceramide-activated* protein phosphatase, Vav, PKCζ, and SAPK/JNK cascade. Ceramide (Egg) downregulates or inhibits AKT, survivin, CDK2, mTOR, and FLIP. Ceramide (Egg) mediates apoptosis, autophagy, cell cycle arrest, mitochondrial dysfunction, redox state shifts, and ROS generation. Ceramide (Egg) can be used for the research of cancer and neurological disease .

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Reference Standards PKC Phosphatase Endogenous Metabolite	Cancer
D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

HY-P11219

TAT-PDHPS1	YAP	Cancer
TAT-PDHPS1 is a YAP inhibitor composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), leading to increased YAP phosphorylation, which inactivates YAP and suppresses the expression of its downstream target genes. TAT-PDHPS1 is potentially useful in ovarian cancer research .

HY-172143

ATUX-8385	Phosphatase	Neurological Disease Cancer
ATUX-8385 is a potent *PP2A* activator. ATUX-8385 binds to PR65 subunit. ATUX-8385 has the potential for the research of cancers and chronic conditions such as Alzheimer’s disease and chronic obstructive pulmonary disease .

HY-135284

FTY720-Mitoxy	Phosphatase	Neurological Disease Inflammation/Immunology
FTY720-Mitoxy is a fingolimod hydrochloride (HY-12005) derivative with neuroprotective and *PP2A* activating activities. FTY720-Mitoxy has the property of targeting mitochondria. In addition, FTY720-Mitoxy protects neurons by reducing inflammatory responses and is used in the study of neurodegenerative diseases such as Parkinson's disease .

HY-101047S1

D-erythro-Sphingosine-13C2,d2 Erythrosphingosine-¹³C₂,d₂; erythro-C18-Sphingosine-¹³C₂,d₂; trans-4-Sphingenine-¹³C₂,d₂	Isotope-Labeled Compounds PKC Endogenous Metabolite Phosphatase	Cancer
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator .

HY-112929B

(1S,2S,3R)-DT-061 1 Publications Verification	Phosphatase	Cancer
(1S,2S,3R)-DT-061 is an enantiomer of DT-061 (HY-112929). DT-061 is an orally active activator of protein phosphatase 2A (PP2A). (1S,2S,3R)-DT-061 can be used as a negative control in the research of KRAS-mutant and MYC-driven lung cancer tumorigenesis .

HY-149097

ITH12711	Phosphatase	Neurological Disease
ITH12711 is a PP2A ligand. ITH12711 is able to cross the blood-brain barrier (BBB). ITH12711 exerts neuroprotection via restoration of PP2A-phosphatase activity .

製品番号	製品名	Target	研究分野

HY-P11219

TAT-PDHPS1	YAP	Cancer
TAT-PDHPS1 is a YAP inhibitor composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), leading to increased YAP phosphorylation, which inactivates YAP and suppresses the expression of its downstream target genes. TAT-PDHPS1 is potentially useful in ovarian cancer research .

製品番号	製品名	Category	Target	構造式

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	天然物 Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator .

HY-101047R

D-erythro-Sphingosine (Standard) Erythrosphingosine (Standard); erythro-C18-Sphingosine (Standard); trans-4-Sphingenine (Standard)	Structural Classification 天然物 Endogenous metabolite Source Classification	Reference Standards PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Standard) is the analytical standard of D-erythro-Sphingosine. This product is intended for research and analytical applications. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

製品番号	製品名	構造式

HY-101047S

D-erythro-Sphingosine-d7 1 Publications Verification
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-101047S1

D-erythro-Sphingosine-13C2,d2
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a *PP2A* activator .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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