Ceramide (Egg)  (Synonyms: Ceramide (Egg, Chicken))

Ceramide (Egg) (Ceramide (Egg, Chicken)) is a ceramide from chicken. Ceramide (Egg) is a sphingomyelin signaling pathway second messenger. Ceramide (Egg) activates PP2A, JNK, p38 MAPK, CAPK, ceramide-activated protein phosphatase, Vav, PKCζ, and SAPK/JNK cascade. Ceramide (Egg) downregulates or inhibits AKT, survivin, CDK2, mTOR, and FLIP. Ceramide (Egg) mediates apoptosis, autophagy, cell cycle arrest, mitochondrial dysfunction, redox state shifts, and ROS generation. Ceramide (Egg) can be used for the research of cancer and neurological disease^[1][2][3].

Ceramide (Egg) induces apoptosis in human leukemia HL-60 cells via p38 MAPK activation, AKT inhibition, and BAX translocation to mitochondria^[1].
Ceramide (Egg) induces apoptosis and G1 cell cycle arrest in human prostate cancer PC-3 cells via PP2A-dependent AKT dephosphorylation, and promotes cytochrome c release and caspase 9 activation via protein kinase Cδ activation^[1].
Ceramide (Egg) induces autophagy in human nasopharyngeal carcinoma cells via JNK-dependent upregulation of LC3 expression^[1].
Ceramide (Egg) induces autophagic cell death in human malignant glioma cells via BNIP3 activation, LC3 upregulation, and disruption of beclin 1-BCL-2 complexes^[1].
Ceramide (Egg) induces G1 cell cycle arrest in human hepatocarcinoma cells via PPARγ activation, p21 upregulation, reduced CDK2/CDK7 activity, and hypophosphorylation of RB (in RB1^+/+ cells)^[1].
Ceramide (Egg) induces p21-dependent G2 cell cycle arrest in human rhabdomyosarcoma cells, which is attenuated by MDM2 overexpression^[1].
Ceramide (Egg) induces apoptosis in human breast cancer cells, and this cytotoxicity is enhanced by Tamoxifen (HY-13757A) pretreatment, leading to increased cell cycle arrest, caspase activation, and mitochondrial outer membrane permeabilization^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ceramide (Egg) induces complete remission in a rat model of natural killer cell large granular leukemia, accompanied by decreased survivin expression^[1].
Ceramide (Egg) (endogenously generated via acid sphingomyelinase) is required for radiation-induced apoptosis in select mouse tissues including the lung, endocardium, pleura, and pericardium^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

477243-06-4

Solid

White to off-white

[Ceramide (Egg)]

Room temperature in continental US; may vary elsewhere.

• [1]. Morad SA, et al. Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer. 2013;13(1):51-65.  [Content Brief]

  [2]. Haimovitz-Friedman A, et al. Ceramide signaling in apoptosis. Br Med Bull. 1997;53(3):539-553.  [Content Brief]

  [3]. Ross MM, et al. Ceramide: a novel inducer for neural tube defects. Dev Dyn. 2019;248(10):979-996.  [Content Brief]