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Peptide nucleic acid

" in MedChemExpress (MCE) Product Catalog:

61

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9

Fluorescent Dyes

3

Biochemical Assay Reagents

39

Peptides

5

Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0178
    1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride
    10+ Cited Publications

    		 Biochemical Assay Reagents Others
    1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification .
    1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride
  • HY-P0311
    LAH4

    		Bacterial Infection
    LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .
    LAH4
  • HY-P4076
    MPG peptides, Pβ

    		HIV DNA Alkylator/Crosslinker Infection
    MPG peptides, Pβ is an amphipathic cell-penetrating peptide. MPG peptides, Pβ consists of three components: the hydrophobic fusion sequence (GALFLGFLGAAGSTMGA) of HIV glycoprotein 41, a spacer domain (WSQP), and the nuclear localization signal (KKKRKV) of the large T antigen of Simian virus 40. MPG peptides, Pβ can form stable non-covalent complexes with nucleic acids (including DNA) through electrostatic interactions and improve their intracellular delivery. MPG peptides, Pβ can be used in studies of HIV-1-related immune responses .
    MPG peptides, Pβ
  • HY-P0311A
    LAH4 TFA

    		Bacterial Infection
    LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 TFA possesses high plasmid DNA delivery capacities. LAH4 TFA has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes .
    LAH4 TFA
  • HY-P3150
    Recombinant Proteinase K

    		Ser/Thr Protease Others
    Recombinant Proteinase K is a serine protease that cleaves the carboxy-terminated peptide bonds of aliphatic and aromatic amino acids. Recombinant Proteinase K can be used to digest proteins and remove contamination from nucleic acid preparations .
    Recombinant Proteinase K
  • HY-D2441
    TAT-PEG-Cy3

    		Fluorescent Dye Cancer
    TAT-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, Cell membrane penetrating peptide (TAT) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. TAT-PEG-Cy3 can be used for cell targeted delivery and biological imaging .
    TAT-PEG-Cy3
  • HY-D2439
    RGD-PEG-Cy3

    		Fluorescent Dye Cancer
    RGD-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 fluorescent dye, peptide (RGD) and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. RGD is a peptide sequence (CRGDKGPDCiRGD) that binds to αvβ3 and αvβ5 integrin receptors on tumor neovasculogenesis to achieve specific tumor tissue targeting .
    RGD-PEG-Cy3
  • HY-W540122
    Fmoc-PNA-C(Bhoc)-OH

    		Biochemical Assay Reagents Others
    Fmoc-PNA-C(Bhoc)-OH is a peptide nucleic acid monomers, and can be used in the synthesis of peptide nucleic acid compounds .
    Fmoc-PNA-C(Bhoc)-OH
  • HY-D2891
    5-TAMRA-DBCO

    		Fluorescent Dye Others
    5-TAMRA-DBCO is a fluorescent dye that combines 5-TAMRA (HY-15942) with a dibenzocyclooctyne (DBCO) moiety. 5-TAMRA-DBCO is able to copper-free click chemistry reactions with azide-functionalized molecules. 5-TAMRA-DBCO can be used for labeling proteins, peptides, nucleic acids (Ex/Em = 541/567 nm) .
    5-TAMRA-DBCO
  • HY-W024881
    Potassium 2,3,3-trimethylindole-5-sulfonate

    2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt

    		 Drug Intermediate Others
    Potassium 2,3,3-trimethylindole-5-sulfonate (2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt) is an indole derivative containing a sodium sulfonate group and is commonly used as a key intermediate in dye synthesis. Potassium 2,3,3-trimethylindole-5-sulfonate can be coupled to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via the sulfonyl substituent .
    Potassium 2,3,3-trimethylindole-5-sulfonate
  • HY-151738
    Fmoc-Aeg(N3)-OH

    		ADC Linker Others
    Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-Aeg(N3)-OH
  • HY-151778
    Fmoc-Abg(N3)-OH

    		ADC Linker Others
    Fmoc-Abg(N3)-OH is a click chemistry reagent containing an azide group. Fmoc-Abg(N3)-OH has the potential to synthesize peptide nucleic acids (PNA) and peptoids. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-Abg(N3)-OH
  • HY-108409
    Progesterone carboxylic acid

    Etienic acid; Testosterone-17β-carboxylic acid; 3-Oxoandrost-4-ene-17β-carboxylic acid

    		 Drug Derivative Metabolic Disease Cancer
    Progesterone carboxylic acid (Testosterone-17β-carboxylic acid) is an androstenedione analogue. Progesterone carboxylic acid can conjugate with 20-mer peptide nucleic acid (PNA) and the conjugate has superior binding capacity on complementary DNA. Progesterone carboxylic acid can be used for cancers and type 2 diabetes (T2D) research .
    Progesterone carboxylic acid
  • HY-P11351
    Precursor-HhH

    		DNA/RNA Synthesis Cancer
    Precursor-HhH is a nucleic acid-binding peptide capable of non-specific interactions with RNA and double-stranded DNA (dsDNA). Precursor-HhH is promising for research of nucleic acid-targeted therapeutics .
    Precursor-HhH
  • HY-W320685
    (S)-N-Boc-L-homoserine ethyl ester

    		Drug Intermediate Others
    (S)-N-Boc-L-homoserine ethyl ester is a synthetic intermediate in the synthesis of unsaturated caprolactams and monomer units for oxy-peptide nucleic acids from the starting material L-homoserine.
    (S)-N-Boc-L-homoserine ethyl ester
  • HY-P2853A
    Hemocyanin-SMCC

    		Biochemical Assay Reagents Others
    Hemocyanin-SMCC is a hemocyanin that can be used as a carrier protein to couple low molecular weight molecules such as peptides, nucleic acids, drugs or toxins to make them highly immunogenic.
    Hemocyanin-SMCC
  • HY-W012443
    3-(Trimethylsilyl)-1-propanesulfonic acid sodium

    		Drug Intermediate Others
    3-(Trimethylsilyl)-1-propanesulfonic acid sodium is a compound derived from 1-propanesulfonic acid and trimethylsilyl. It can be used as a versatile reagent in the preparation of peptides, proteins, and nucleic acids .
    3-(Trimethylsilyl)-1-propanesulfonic acid sodium
  • HY-P1566
    MPG, HIV related

    		HIV Infection
    MPG, HIV related is 27-aa peptide, derived from both the nuclear localisation sequence of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41 and is a potent delivery agent for the generalised delivery of nucleic acids and of oligonucleotides into cultured cells.
    MPG, HIV related
  • HY-W879234
    TriSulfo-Cy5.5 DBCO

    Sulfo Cy5.5-DBCO

    		 Fluorescent Dye Others
    TriSulfo-Cy5.5 DBCO is a near infrared (NIR) fluorescent anthocyanin fluorescent dye.TriSulfo-Cy5.5 DBCO can be used to label proteins, antibodies, peptides, nucleic acid molecules.
    TriSulfo-Cy5.5 DBCO
  • HY-155995
    PRO-905

    MK-905

    		 Biochemical Assay Reagents Cancer
    Pro-905 is a phosphite peptide with antitumor activity. Pro-905 delivers the active nucleotide antimetabolite thioguanosine monophosphate (TGMP) to the tumor. Pro-905 effectively prevents incorporation of purine salvage substrates into nucleic acids and inhibits colony formation in human malignant peripheral nerve sheath tumors (MPNST) cells. Pro-905 inhibits purine salvage incorporation to nucleic acids and prevents cell growth. Pro-905 inhibits the growth of MPNST and enhances the anti-tumor efficacy of JHU395 (HY-124778) .
    PRO-905
  • HY-174289
    TMTHSI succinimide NHS ester

    		Biochemical Assay Reagents Others
    TMTHSI succinimide NHS ester is a highly efficient cyclic alkyne click reagent. TMTHSI succinimide NHS ester has the primary activity to rapidly undergo strain-promoted cycloaddition reactions with azides. TMTHSI succinimide NHS ester is easily functionalized and can be linked to a variety of small molecules and (peptides, nucleic acids) biologics via a variety of linkers .
    TMTHSI succinimide NHS ester
  • HY-D2758
    TAMRA DBCO, 5-isomer

    		Fluorescent Dye Others
    TAMRA DBCO, 5-isomer is a derivative of tetramethylrhodamine (TMR, TAMRA) containing a cyclooctyne moiety (dibenzocyclooctyne, DBCO). Pure 5-isomer. DBCO reacts quickly and efficiently with azides by simply mixing the components without the need for a copper catalyst (so-called sterically promoted cycloaddition reaction (SPAAC)). TAMRA DBCO can be used for the labeling of proteins, peptides, nucleic acids, and other molecules containing azide groups.
    TAMRA DBCO, 5-isomer
  • HY-W025936
    Fmoc-PNA-G(Bhoc)-OH

    		Drug Intermediate Others
    Fmoc‑PNA‑G (Bhoc)‑OH is a guanine-containing peptide nucleic acid monomer, in which both Bhoc on the nucleobase and Fmoc on the backbone serve as protecting groups. Fmoc‑PNA‑G (Bhoc)‑OH is applicable for the synthesis of peptide nucleic acids .
    Fmoc-PNA-G(Bhoc)-OH
  • HY-W784625
    Boc-PNA-G(Z)-OH

    		Drug Intermediate Others
    Boc-PNA-G(Z)-OH is a peptide nucleic acid (PNA) monomer that is used for the synthesis of peptide nucleic acid oligomers .
    Boc-PNA-G(Z)-OH
  • HY-170991
    C12-rrw-NH2

    		Bacterial Reactive Oxygen Species (ROS) Infection
    C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). C12-rrw-NH2 induces bacterial death via depolarizing the bacterial cytoplasmic membrane, disrupting the integrity of the bacterial membrane, leading to leakage of nucleic acid and protein and promoting the generation of Reactive Oxygen Species. C12-rrw-NH2 is potential to be used for research of developing high-stability antimicrobial peptides .
    C12-rrw-NH2
  • HY-P11687
    Fmoc-PNA-M(Boc)-OH

    		Drug Intermediate Others
    Fmoc-PNA-M(Boc)-OH is a peptide nucleic acid monomer with Fmoc and Boc protecting groups. Fmoc-PNA-M(Boc)-OH can be used for synthesis of peptide nucleic acid .
    Fmoc-PNA-M(Boc)-OH
  • HY-W784624
    Boc-PNA-C(Z)-OH

    		Drug Intermediate Others
    Boc‑PNA‑C (Z)‑OH is a cytosine-containing peptide nucleic acid monomer, in which the amino group and cytosine are protected by tert-butoxycarbonyl (Boc) and benzyloxycarbonyl groups, respectively. Boc‑PNA‑C (Z)‑OH can be used for the synthesis of peptide nucleic acids .
    Boc-PNA-C(Z)-OH
  • HY-W665456
    Fmoc-PNA-U-OH

    		Drug Intermediate Others
    Fmoc‑PNA‑U‑OH is a peptide nucleic acid monomer that can be used for the synthesis of peptide nucleic acids (PNAs). Fmoc‑PNA‑U‑OH exhibits specific binding to adenine, resistance to enzymatic degradation, and strong hybridization properties. Fmoc‑PNA‑U‑OH can be applied in research fields such as gene diagnosis, molecular biology, and antisense therapy.
    Fmoc-PNA-U-OH
  • HY-160513
    Fmoc-PNA-Abasic(Boc)-OH

    		DNA/RNA Synthesis Others
    Fmoc‑PNA‑Abasic(Boc)‑OH is a synthetic peptide nucleic acid modified with Fmoc and Boc protecting groups. Fmoc‑PNA‑Abasic(Boc)‑OH can be used in molecular biology research.
    Fmoc-PNA-Abasic(Boc)-OH
  • HY-130510
    6-HEX dipivaloate

    		Fluorescent Dye Others
    6-HEX dipivaloate is an amino-bindable fluorescent probe that can be used to label peptides and oligonucleotides. 6-HEX dipivaloate is widely used in nucleic acid sequencing and related research .
    6-HEX dipivaloate
  • HY-W402665
    Fmoc-PNA-T-OH

    Fmoc-C(Bhoc)-Aeg-OH

    		 Drug Intermediate Metabolic Disease
    Fmoc-PNA-T-OH (Fmoc-C (Bhoc)-Aeg-OH) is a Bhoc-protected peptide nucleic acid (PNA) monomer. Fmoc-PNA-T-OH is used in the research of type 2 diabetes (t2d) .
    Fmoc-PNA-T-OH
  • HY-W784623
    Boc-PNA-A(Z)-OH

    		Drug Intermediate Others
    Boc-PNA-A(Z)-OH is a Boc-protected peptide nucleic acid monomer with a benzyloxycarbonyl protecting group on the adenine base .
    Boc-PNA-A(Z)-OH
  • HY-W784626
    Boc-PNA-T-OH

    		Drug Intermediate Others
    Boc-PNA-T-OH is a thymine-containing peptide nucleic acid monomer and solid-phase synthesis building block .
    Boc-PNA-T-OH
  • HY-W574398
    Fmoc-Aeg-OH

    		Biochemical Assay Reagents Others
    Fmoc-Aeg-OH is a peptide nucleic acid (PNA) backbone intermediate and an Fmoc-protected carboxylic acid. Fmoc-Aeg-OH can be coupled with base acetic acids to synthesize Fmoc-protected PNA monomers, including those with modified bases .
    Fmoc-Aeg-OH
  • HY-P11691
    Fmoc-PNA-D(tetraBoc)-OH

    		Biochemical Assay Reagents Others
    Fmoc-PNA-D (tetraBoc)-OH is an Fmoc/Boc-protected diaminopurine peptide nucleic acid (PNA) monomer suitable for standard Fmoc solid-phase synthesis. Fmoc-PNA-D (tetraBoc)-OH carries Boc-protected exocyclic amino groups and can be incorporated into pseudo-complementary PNA oligomers for applications in antigenic peptide nucleic acid and DNA nanotechnology research .
    Fmoc-PNA-D(tetraBoc)-OH
  • HY-P11695
    Fmoc-Aeg(Dde)

    		Biochemical Assay Reagents Others
    Fmoc-Aeg (Dde) is a protected aminoethylglycine (AEG) monomer used for solid-phase synthesis of peptide nucleic acids (PNAs). Fmoc-Aeg (Dde) contains the fluorenylmethoxycarbonyl (Fmoc) and 1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl (Dde) protecting groups .
    Fmoc-Aeg(Dde)
  • HY-108409R
    Progesterone carboxylic acid (Standard)

    Etienic acid (Standard); Testosterone-17β-carboxylic acid (Standard); 3-Oxoandrost-4-ene-17β-carboxylic acid (Standard)

    		 Reference Standards Drug Derivative Metabolic Disease Cancer
    Progesterone carboxylic acid (Standard) is the analytical standard of Progesterone carboxylic acid (HY-108409). This product is intended for research and analytical applications. Progesterone carboxylic acid (Testosterone-17β-carboxylic acid) is an androstenedione analogue. Progesterone carboxylic acid can conjugate with 20-mer peptide nucleic acid (PNA) and the conjugate has superior binding capacity on complementary DNA. Progesterone carboxylic acid can be used for cancers and type 2 diabetes (T2D) research .
    Progesterone carboxylic acid (Standard)
  • HY-P11689
    Fmoc-PNA-J(Bhoc)-OH

    		Biochemical Assay Reagents Others
    Fmoc-PNA-J (Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer building block used for solid-phase synthesis of PNA oligomers. Fmoc-PNA-J (Bhoc)-OH carries Fmoc/Bhoc protecting groups and functions as a standard Fmoc-protected PNA monomer .
    Fmoc-PNA-J(Bhoc)-OH
  • HY-P11688
    Fmoc-PNA-M(Bhoc)-OH

    		Biochemical Assay Reagents Others
    Fmoc-PNA-M (Bhoc)-OH is a standard peptide nucleic acid (PNA) monomer building block. Fmoc-PNA-M (Bhoc)-OH carries two protecting groups, Fmoc and Bhoc, and is specifically designed for solid-phase and automated PNA synthesis. Fmoc-PNA-M (Bhoc)-OH efficiently participates in the construction of sequence-specific PNA probes. Through its protecting group strategy, Fmoc-PNA-M (Bhoc)-OH ensures the accuracy and efficiency of PNA synthesis, and is one of the important raw materials for PNA synthesis at present .
    Fmoc-PNA-M(Bhoc)-OH
  • HY-W540123
    Fmoc-PNA-A(Bhoc)-OH

    		Biochemical Assay Reagents Cancer
    Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration .
    Fmoc-PNA-A(Bhoc)-OH
  • HY-W415169
    H-Aeg(Fmoc)-OBzl hydrochloride

    		Drug Intermediate Others
    H-Aeg(Fmoc)-OBzl hydrochloride is an Fmoc-protected aminoethylglycine derivative with benzyl ester and can be used for synthesis of peptide nucleic acid and protected oligomers.
    H-Aeg(Fmoc)-OBzl hydrochloride
  • HY-P11696
    H-Aeg(Fmoc)-OH hydrochloride

    		Drug Intermediate Others
    H-Aeg(Fmoc)-OH hydrochloride is an Fmoc-protected aminoethylglycine monomer with a free carboxyl group and can be used for peptide nucleic acid synthesis.
    H-Aeg(Fmoc)-OH hydrochloride
  • HY-P11679
    Boc-PNA-U-OH

    		DNA/RNA Synthesis Others
    Boc-PNA-U-OH is a protected peptide nucleic acid (PNA) monomer containing a uracil base, designed for solid-phase peptide synthesis (SPPS) using the Boc/Z protection strategy. Boc-PNA-U-OH acts as a building block in creating PNA oligomers that are neutral, stable, and used for antisense/antigene applications.
    Boc-PNA-U-OH
  • HY-P11682
    Boc-PNA-M(Z)-OH

    		DNA/RNA Synthesis Others
    Boc-PNA-M(Z)-OH is a protected peptide nucleic acid (PNA) monomer used in solid-phase peptide synthesis (SPPS). Boc-PNA-M(Z)-OH consists of an adenyl base protected with a benzyloxycarbonyl (Z) group and a backbone protected with a tert-butyloxycarbonyl (Boc) group, typically used for creating PNA oligomers.
    Boc-PNA-M(Z)-OH
  • HY-P11729
    Mitochondria rRNA blocker

    		Biochemical Assay Reagents Others
    Mitochondria rRNA blocker is a PCR blocker based on peptide nucleic acid (PNA). Mitochondria rRNA blocker targets the conserved 16S rRNA sequence of mitochondria and can be used in research involving PCR, sequencing, and gene detection.
    Mitochondria rRNA blocker
  • HY-P11697
    Fmoc-PNA-maleimide-OH

    		Drug Intermediate Others
    Fmoc-PNA-maleimide-OH is a Fmoc-protected functionalized peptide nucleic acid monomer featuring a maleimide group for thiol-reactive conjugation. Fmoc-PNA-maleimide-OH can be used in constructing PNA conjugates for molecular assembly applications.
    Fmoc-PNA-maleimide-OH
  • HY-P11730
    Chloroplast rRNA blocker

    		Biochemical Assay Reagents Others
    Chloroplast rRNA blocker is a chloroplast rRNA-specific peptide nucleic acid (PNA) blocker. Chloroplast rRNA blocker targets the conserved 16S rRNA sequence in plants and can be used in research involving PCR, sequencing, and gene detection.
    Chloroplast rRNA blocker
  • HY-P11683
    Boc-PNA-D(tetraZ)-OH

    		DNA/RNA Synthesis Others
    Boc-PNA-D(tetraZ)-OH is a specialized Peptide Nucleic Acid (PNA) monomer used in solid-phase peptide synthesis, featuring a N-tert-butoxycarbonyl (Boc) protected backbone and a 2,6-diaminopurine nucleobase. Boc-PNA-D(tetraZ)-OH helps increase PNA solubility and binding affinity, often used in molecular diagnostics.
    Boc-PNA-D(tetraZ)-OH
  • HY-P11759
    Myr-transportan-Cys

    		Drug Derivative Cancer
    Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors .
    Myr-transportan-Cys
  • HY-P11732
    acpP PNA

    		Bacterial Infection
    acpP PNA is a 10-mer peptide nucleic acid targeting the bacterial essential gene acpP. acpP PNA can inhibit bacterial growth and reduce the level of target transcripts, and still retains activity with double terminal mismatches. acpP PNA may also cause off-target effects .
    acpP PNA

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