Fmoc-PNA-A(Bhoc)-OH 

Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration^[1][2][3].

Fmoc-PNA-A(Bhoc)-OH (165-331 μM; 2 h) produces the adenine PNA hexamer A6 with a 54% yield and 97.4% purity^[1].
Fmoc-PNA-A(Bhoc)-OH (344 μM; 2 h) produces the adenine PNA monomer mA with a 48% yield and 72% purity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

¹²⁵I- and ¹¹¹In-labeled Fmoc-PNA-A(Bhoc)-OH (HP2) (20 kBq (1 μg) of ¹¹¹In-labeled derivative; 10 kBq (1 μg) of ¹²⁵I-labeled derivative; i.v.; single dose) exhibit very fast blood clearance and low, decreasing kidney accumulation in normal NMRI mice over 4 hours post-injection^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

725.75

C₄₀H₃₅N₇O₇

186046-82-2

Solid

White to off-white

Room temperature in continental US; may vary elsewhere.

• [1]. Petkowski JJ, et al. Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid. Sci Adv. 2025;11(13):eadr0006.  [Content Brief]

  [2]. Yagita R, Murakami K, Ikeda H, et al. Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid[J]. Tetrahedron Letters, 2020, 61(17): 151781.

  [3]. Westerlund K, et al. Design, Preparation, and Characterization of PNA-Based Hybridization Probes for Affibody-Molecule-Mediated Pretargeting. Bioconjug Chem. 2015;26(8):1724-1736.  [Content Brief]