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Cat. No.: HY-D2758

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TAMRA DBCO, 5-isomer

TAMRA DBCO, 5-isomer is a derivative of TAMRA fluorescent isomer with a DBCO functional group. TAMRA DBCO, 5-isomer undergoes strain-promoted azide-alkyne cycloaddition (SPAAC) under copper-free catalytic conditions. TAMRA DBCO, 5-isomer serves as a FRET acceptor for FAM fluorophores. TAMRA DBCO, 5-isomer can label proteins, peptides, nucleic acids and all azide-modified biomolecules, and is suitable for fluorescence imaging and flow cytometry to quantify intracellular SPAAC reactions.

For research use only. We do not sell to patients.

CAS No.: 1911598-65-6
Formula: C₄₆H₄₂N₄O₅
Molecular Weight:730.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TAMRA DBCO, 5-isomer Chemical Structure

CAS No.: 1911598-65-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

TAMRA DBCO, 5-isomer is a derivative of tetramethylrhodamine (TMR, TAMRA) that contains a cyclooctyne moiety (dibenzocyclooctyne, DBCO). DBCO reacts rapidly and efficiently with azides simply by mixing the components, without the need for a copper catalyst (i.e., strain-promoted azide-alkyne cycloaddition (SPAAC))^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1911598-65-6
Molecular Weight 730.85
Formula C₄₆H₄₂N₄O₅
SMILES

O=C(C1=C(C2=C3C=CC(N(C)C)=CC3=[O+]C4=C2C=CC(N(C)C)=C4)C=CC(C(NCCCCCC(N5C6=C(C#CC7=C(C5)C=CC=C7)C=CC=C6)=O)=O)=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kovacs L, et al. Development of an In Vitro Assay for Evaluation of Intracellular SPAAC Reactions Using Hoechst-DBCO. Chem Biomed Imaging. 2025;4(5):912-923. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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