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Results for "

QC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Decarboxylase (2) Amyloid-β (2) Apoptosis (4) CD47 (2) Heme Oxygenase (HO) (1) Histone Acetyltransferase (1) Histone Demethylase (6) Huntingtin (1) Ligands for Target Protein for PROTAC (1) PROTACs (2) Reference Standards (2) Small Interfering RNA (siRNA) (4) Tau Protein (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Metabolic Disease (2) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-104048

QC6352 10+ Cited Publications	Histone Demethylase	Cancer
QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

HY-148807

Zavondemstat QC8222 free base; TACH 101 free base	Histone Demethylase Apoptosis	Cancer
Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-134850

QC-01–175	PROTACs Tau Protein	Neurological Disease
QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)) .

HY-136780

SEN177	Amyloid-β Apoptosis CD47 Huntingtin	Neurological Disease Cancer
SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The K_i of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC₅₀ is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases .

HY-W453397

Aberrant tau ligand 1	Ligands for Target Protein for PROTAC Tau Protein	Cardiovascular Disease Neurological Disease
Aberrant tau ligand 1 is a tau protein ligand. Aberrant tau ligand 1 engages tau and CRBN to trigger proteasomal degradation. Aberrant tau ligand 1 can be used for synthesis PROTACs, such as QC-01–175 (HY-134850) .

HY-103391

Qc1	Amino Acid Decarboxylase	Metabolic Disease
Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease .

HY-162259

QC-182	PROTACs Histone Acetyltransferase	Cancer
QC-182 is a potent PROTAC degrader of p300/CBP. QC-182 reduces p300 protein in the SK-HEP-1 cells (DC₅₀ = 93nM). QC-182 potently and effectively inhibits cell growth in the SK-HEP-1 and JHH7 cell lines with IC₅₀ values of 0.733 and 0.477 μM, respectively. QC-182 can be used for the research of hepatocellular carcinoma (HCC) .

HY-151132

Glutaminyl cyclases-IN-1 IsoQC-IN-1	CD47	Cancer
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC₅₀ values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .

HY-148807B

(S)-Zavondemstat (S)-QC8222 free base; (S)-TACH 101 free base	Histone Demethylase	Others
(S)-Zavondemstat is the S-enantiomer of Zavondemstat (HY-148807). Zavondemstat is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity ^{[1] ^.}

HY-148807A

Zavondemstat L-lysine QC8222; TACH 101	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) L-lysine is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat L-lysine induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat L-lysine suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat L-lysine can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-RS01721

C1QC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C1QC Human Pre-designed siRNA Set A contains three designed siRNAs for C1QC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1QC Human Pre-designed siRNA Set A C1QC Human Pre-designed siRNA Set A

HY-148807C

Zavondemstat sodium QC8222 sodium; TACH 101 sodium	Apoptosis Histone Demethylase	Cancer
Zavondemstat (QC8222; TACH 101) sodium is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat sodium induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat sodium suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat sodium can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-RS11501

QPCT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
QPCT Human Pre-designed siRNA Set A contains three designed siRNAs for QPCT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

QPCT Human Pre-designed siRNA Set A QPCT Human Pre-designed siRNA Set A

HY-152031

Glutaminyl Cyclase Inhibitor 5	Amyloid-β	Neurological Disease
Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and selective human glutaminyl cyclase (hQC) inhibitor with an IC₅₀ of 3.2 nM .

HY-182604

QC-308	Heme Oxygenase (HO)	Cancer
QC-308 is a HO-1/HO-2 inhibitor with an HO-1 IC₅₀ of 0.27 μM and an HO-2 IC₅₀ of 0.46 μM. QC-308 coordinates heme iron(II) to disrupt catalysis. QC-308 can be used for research of HO-1 inhibition mechanisms in cancer .

HY-103391R

Qc1 (Standard)	Amino Acid Decarboxylase Reference Standards	Metabolic Disease
Qc1 (Standard) is the analytical standard of Qc1 (HY-103391). This product is intended for research and analytical applications. Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease .

HY-104048R

QC6352 (Standard)	Reference Standards Histone Demethylase	Cancer
QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

HY-RS26378

C1qc Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C1qc Rat Pre-designed siRNA Set A contains three designed siRNAs for C1qc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1qc Rat Pre-designed siRNA Set A C1qc Rat Pre-designed siRNA Set A

HY-RS19879

C1qc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
C1qc Mouse Pre-designed siRNA Set A contains three designed siRNAs for C1qc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1qc Mouse Pre-designed siRNA Set A C1qc Mouse Pre-designed siRNA Set A

Species:	Human (1) Mouse (2) E.coli (1)
Tag:	His (4) Myc (1)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71670

	QPCT Protein, Mouse (HEK293, His-Myc) Qpct; Glutaminyl-peptide cyclotransferase; EC 2.3.2.5; Glutaminyl cyclase; QC; Glutaminyl-tRNA cyclotransferase	Mouse	HEK293
	The QPCT protein plays a key role in pyroglutamyl peptide biosynthesis and exhibits substrate preference for N-terminal glutamine residues while showing specificity for residues near the N-terminus. Notably, its catalytic activity is independent of chain length beyond the second residue, emphasizing the importance of QPCT in the precise biosynthesis of pyroglutamyl peptides with diverse N-termini, contributing to various biological background. QPCT Protein, Mouse (HEK293, His) is the recombinant mouse-derived QPCT protein, expressed by HEK293 , with N-His, N-Myc labeled tag.

HY-P76560

	QPCT Protein, Human (sf9, His) Glutaminyl-peptide cyclotransferase; QC; Glutamyl cyclase; EC	Human	Sf9 insect cells
	QPCT Protein synthesizes pyroglutamyl peptides, favoring N-terminal glutaminyl residue over adjacent acidic and tryptophan residues. It catalyzes N-terminal pyroglutamate formation, particularly [Glu-3]-amyloid-beta in APP peptides. In lab settings, it aids pyroglutamate formation in truncated amyloid-beta peptides. QPCT Protein may contribute to N-terminal pyroglutamate formation in peptides linked to amyloid-related plaque development. QPCT Protein, Human (sf9, His) is the recombinant human-derived QPCT protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P70247

	LacI Protein, E.coli (Q360QC, His) rE.coLactose operon repressor/LacI, His; Lactose operon repressor; LacI	E.coli	E. coli
	LacI, the lactose operon repressor, regulates lactose metabolism by binding to the operator region and repressing gene transcription. The presence of the inducer, allolactose, alters its binding affinity, derepressing the operon. As a homotetramer, LacI finely tunes lactose metabolism, orchestrating regulatory mechanisms in response to the cellular environment. LacI Protein, E.coli (Q360QC, His) is the recombinant E. coli-derived LacI protein, expressed by E. coli , with N-10*His labeled tag and Q360QC mutation.

HY-P71670A

	QPCT Protein, Mouse (His) Qpct; Glutaminyl-peptide cyclotransferase; EC 2.3.2.5; Glutaminyl cyclase; QC; Glutaminyl-tRNA cyclotransferase	Mouse	E. coli
	The QPCT protein plays a key role in pyroglutamyl peptide biosynthesis and exhibits substrate preference for N-terminal glutamine residues while showing specificity for residues near the N-terminus. Notably, its catalytic activity is independent of chain length beyond the second residue, emphasizing the importance of QPCT in the precise biosynthesis of pyroglutamyl peptides with diverse N-termini, contributing to various biological background. QPCT Protein, Mouse (His) is the recombinant mouse-derived QPCT protein, expressed by E. coli , with N-6*His tag.

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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Rat (1)
Application:	IHC-P (1) WB (1) FC (2) ELISA (2)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810324

	C1QC Antibody C1QG, C1QC, Complement C1q subcomponent subunit C	WB, IHC-P	Human, Rat
	C1QC Antibody is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to C1QC.

HY-P87405

	C1QC Antibody (YA7093)	FC, ELISA	Human
	C1QC Antibody (YA7093) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1QC.

HY-P87405A

	C1QC Antibody (YA7093)(PBS only) C1QG, C1QC, Complement C1q subcomponent subunit C	FC, ELISA	Human
	C1QC Antibody (YA7093) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1QC.

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C1QC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
C1QC Human Pre-designed siRNA Set A contains three designed siRNAs for C1QC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

QPCT Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
QPCT Human Pre-designed siRNA Set A contains three designed siRNAs for QPCT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1qc Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
C1qc Rat Pre-designed siRNA Set A contains three designed siRNAs for C1qc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

C1qc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
C1qc Mouse Pre-designed siRNA Set A contains three designed siRNAs for C1qc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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