Glutaminyl Cyclase Inhibitor 5
Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and selective human glutaminyl cyclase (hQC) inhibitor with an IC50 of 3.2 nM.
For research use only. We do not sell to patients.
- CAS No.: 3033553-63-5
- Formula: C22H30N6O
- Molecular Weight:394.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 3.2 nM (hQC), 34.2 nM (mQC), 106.1 nM (isoQC)[1]
Glutaminyl Cyclase Inhibitor 5 (Compound 71) does not show significant hERG inhibition (47.6% inhibition at 10 μM)[1].
Glutaminyl Cyclase Inhibitor 5 exhibits reasonable permeability with less than a cutoff value of 6.0 (-log Pe) and is likely to be BBB permeable[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, six weeks old), acute Alzheimer's disease model[1]
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Dosage:10 mM, 5 μL
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Administration:Intracerebroventricular injection, once
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Result:Suppressed the formation of pE-Aβ3-40 by 25.0%.
Chemical Information
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CAS No. 3033553-63-5
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Molecular Weight 394.51
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Formula C22H30N6O
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SMILES
CC1=CN=CN1CCCNC(N(C2CCCCC2)C3=CC4=C(C(C)=NN4)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glutaminyl Cyclase Inhibitor 5 Related Classifications
HY-152031 Related Classifications
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