C1QC Antibody (YA7093)(PBS only)
(Synonyms: C1QG, C1QC, Complement C1q subcomponent subunit C)C1QC Antibody (YA7093) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1QC.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
C1QC Antibody (YA7093) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1QC.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 25.7kDa;
Purified recombinant fragment of human C1QC (AA: 115-245) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C1QC core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system[1][2][3][4][5][6][7][8][9][10].
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Subcellular Localization
Secreted,Cell surface
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Isoforms & Post-Translational Modification
P02747: 245 amino acids, molecular weight 25774 Da.
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Subunit
Core component of the complement C1 complex, a calcium-dependent complex composed of 1 molecule of the C1Q subcomplex, 2 molecules of C1R and 2 molecules of C1S (PubMed:23650384, PubMed:29449492, PubMed:34155115, PubMed:6249812)
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SwissProt ID
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Synonyms
C1QG, C1QC, Complement C1q subcomponent subunit C
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