C1QC Antibody (YA7093)(PBS only)
(別名: C1QG, C1QC, Complement C1q subcomponent subunit C)C1QC Antibody (YA7093) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1QC.
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Host:
Mouse
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Isotype:
IgG1
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:400 | 1:10000 |
Product Details
C1QC Antibody (YA7093) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C1QC.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 25.7kDa;
Purified recombinant fragment of human C1QC (AA: 115-245) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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輸送条件
Shipping with blue ice.
Background
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Function
Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12847249, PubMed:19006321, PubMed:24626930, PubMed:29449492, PubMed:3258649, PubMed:34155115, PubMed:6249812, PubMed:6776418). The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain (PubMed:12847249, PubMed:19006321, PubMed:24626930, PubMed:29449492, PubMed:3258649, PubMed:6776418). Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system (PubMed:29449492). The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed:19706439, PubMed:24626930, PubMed:29449492). The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system (PubMed:18250442)
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Subcellular Localization
Secreted,Cell surface
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Isoforms & Post-Translational Modification
P02747: 245 amino acids, molecular weight 25774 Da.
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Subunit
Core component of the complement C1 complex, a calcium-dependent complex composed of 1 molecule of the C1Q subcomplex, 2 molecules of C1R and 2 molecules of C1S (PubMed:23650384, PubMed:29449492, PubMed:34155115, PubMed:6249812)
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SwissProt ID
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別名
C1QG, C1QC, Complement C1q subcomponent subunit C
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