1. Epigenetics
  2. Histone Demethylase
  3. QC6352

QC6352 

Cat. No.: HY-104048 Purity: >98.0%
Handling Instructions

QC6352 is a potent KDM4C inhibitor with an IC50 of 35 nM.

For research use only. We do not sell to patients.

QC6352 Chemical Structure

QC6352 Chemical Structure

CAS No. : 1851373-36-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 460 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2640 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3960 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

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  • Purity & Documentation

  • References

Description

QC6352 is a potent KDM4C inhibitor with an IC50 of 35 nM.

IC50 & Target

IC50: 35 nM (KDM4C)[1]

In Vitro

QC6352 is a potent KDM4C inhibitor with an IC50 of 35±8 nM[1]. In a concentration-dependent manner QC6352 dramatically reduces the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. QC6352 blocks proliferation and self-renewal of BCSCs. As shown by western blot analysis the protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352[2].

In Vivo

QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (64.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5808 mL 12.9042 mL 25.8084 mL
5 mM 0.5162 mL 2.5808 mL 5.1617 mL
10 mM 0.2581 mL 1.2904 mL 2.5808 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Cells are detached by Accutase and counted. 1×103 single BCSC1 and BCSC2 cells are seeded as triplicates in 50% Matrigel into individual wells of 24-well ultra-low attachment plates in serum-free MSC medium. After 7 days, spheres over 50 μm diameter are counted for QC6352- and QC6688-treated and control cells and spheres over 20 μm diameter are counted for paclitaxel-treated and control cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Mice: When tumors reach a palpable size of 3 mm3, mice are treated with vehicle (control) or QC6352. The inhibitor is administered daily to mice via oral gavage at 10 mg/kg. Control animals receive vehicle only. Animals are monitored twice weekly for weight and tumor growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

387.47

Formula

C₂₄H₂₅N₃O₂

CAS No.

1851373-36-8

SMILES

O=C(C1=C(NC[[email protected]@H]2CCCC3=C2C=CC(N(C)C4=CC=CC=C4)=C3)C=NC=C1)O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
QC6352
Cat. No.:
HY-104048
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QC6352

Cat. No.: HY-104048