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Telomerase Reverse Transcriptase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reverse Transcriptase (10) Telomerase (14) Antibiotic (2) AP-1 (1) Apoptosis (10) Bacterial (1) Bcl-2 Family (1) Cytochrome P450 (2) Dopamine β-hydroxylase (2) Drug Derivative (1) Drug Isomer (1) ERK (1) G-quadruplex (1) HIV (8) Influenza Virus (2) MEK (1) Monoamine Oxidase (2) mRNA (2) PKC (2) PROTACs (1) Ras (1) Reference Standards (3)
By Research Areas:	Cancer (14) Infection (10) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	mRNA (1)

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Natural
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Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Reverse Transcriptase Telomerase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0453

Hypericin 5+ Cited Publications	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, **reverse transcriptase*, telomerase* and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-17423

Abacavir 5 Publications Verification	HIV Reverse Transcriptase Telomerase Apoptosis	Infection Cancer
Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-17423A

Abacavir sulfate 5 Publications Verification Abacavir Hemisulfate; ABC sulfate	Reverse Transcriptase HIV Telomerase Apoptosis	Infection Cancer
Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-402361

TERT activator-1	MEK ERK AP-1	Neurological Disease Inflammation/Immunology
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging .

HY-174351

NU-PRO-1	PROTACs Telomerase	Cancer
NU-PRO-1 is a covalent **Telomerase reverse transcriptase (TERT) PROTAC** degrader. NU-PRO-1 induces transient, VHL- and proteasome-dependent proteasomal degradation of TERT in cancer cells. NU-PRO-1 delays DNA repair in irradiated cancer cells without inducing DNA damage on its own. NU-PRO-1 can be used for the research of cancer .

HY-N0453R

Hypericin (Standard) 5+ Cited Publications	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, **reverse transcriptase*, telomerase* and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-105067A

Tertomotide hydrochloride GV-1001 hydrochloride	Telomerase	Neurological Disease
Tertomotide (GV1001) hydrochloride is peptide vaccine consists a 16-aa human telomerase reverse transcriptase (hTERT) sequence. Tertomotide hydrochloride shows neuroprotective. Tertomotide hydrochloride has the potential for the research of Alzheimer's disease .

HY-122482

β-Rubromycin	HIV Reverse Transcriptase Telomerase Bacterial	Infection Metabolic Disease Cancer
β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a K_i of 0.27 μM. β-Rubromycin is a potent *telomerase* inhibitor with an IC₅₀ of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC₅₀ values of 19.5 µM and 22.7 µM, respectively .

HY-17423I

(R,R)-Abacavir	HIV Reverse Transcriptase Telomerase Apoptosis Drug Isomer	Infection Cancer
(R,R)-Abacavir is the (R,R)-enantiomer of Abacavir (HY-17423). Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity .

HY-174537

Human TERT mRNA	mRNA	Cancer
Human TERT mRNA encodes the human telomerase reverse transcriptase (TERT) protein, a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

HY-150361

Mouse Tert mRNA	mRNA	Cancer
Mouse Tert mRNA encodes the mouse telomerase reverse transcriptase (Tert) protein that plays important roles in aging and antiapoptosis.

HY-169518

TERT activator-2	Telomerase	Cancer
TERT activator-2 (Compound 1030) is a telomerase reverse transcriptase (TERT) activator that can increase the expression of TERT in cells. TERT activator-2 can be used in telomere-related cell lifespan research .

HY-17423E

Abacavir hydrochloride	HIV Apoptosis Reverse Transcriptase Telomerase	Infection Cancer
Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-17423B

Abacavir monosulfate 5 Publications Verification	HIV Reverse Transcriptase Telomerase Apoptosis	Infection Cancer
Abacavir monosulfate is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir monosulfate can inhibits the replication of HIV. Abacavir monosulfate shows anticancer activity in prostate cancer cell lines. Abacavir monosulfate can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-17423R

Abacavir (Standard)	Reference Standards HIV Reverse Transcriptase Telomerase Apoptosis	Infection Cancer
Abacavir (Standard) is the analytical standard of Abacavir. This product is intended for research and analytical applications. Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses *telomerase* activity .

HY-17423AR

Abacavir sulfate (Standard) Abacavir Hemisulfate (Standard); ABC sulfate (Standard)	Reference Standards Reverse Transcriptase HIV Telomerase Apoptosis	Infection
Abacavir (sulfate) (Standard) is the analytical standard of Abacavir (sulfate). This product is intended for research and analytical applications. Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity .

HY-179480

G-quadruplex ligand 4	Drug Derivative G-quadruplex Apoptosis Telomerase Ras Bcl-2 Family	Cancer
G-quadruplex ligand 4 is a chromenone derivative and is a *human telomerase* reverse transcriptase (hTERT) G4 ligand. G-quadruplex ligand 4 downregulates hTERT expression and exhibits notable cytotoxicity towards triple-negative breast cancer (TNBC) cell lines. G-quadruplex ligand 4 can cause S/G2 cell cycle arrest and induce apoptosis. G-quadruplex ligand 4 downregulates the expression of hTERT, KRAS, and BCL-2**. G-quadruplex ligand 4 can be used for the research of TNBC .

Hypericin 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Anthraquinones Guttiferae Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, **reverse transcriptase*, telomerase* and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

Hypericin (Standard) 5+ Cited Publications	Natural Products Classification of Application Fields Guttiferae Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, **reverse transcriptase*, telomerase* and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704039

	TERT Protein, Human (His) CMM9; DKCA2; DKCB4; EST2; HEST2; htert; hTRT; PFBMFT1; TCS1; Telomerase associated protein 2; Telomerase catalytic subunit; Telomerase Reverse Transcriptase; Telomerase-associated protein 2; Telomere Reverse Transcriptase; TERT; TERT_HUMAN; TP2; TRT	Human	E. coli
	TERT Protein, Human (His) is the recombinant human-derived TERT protein, expressed by E. coli, with N-6*His tag.

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (1) Mouse (1)
Application:	IHC-P (1) ICC/IF (1) IHC-F (1) WB (2) FC (1) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (1)
Clonality:	Polyclonal (1) Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

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HY-P81110A

	TERT Antibody (YA3439) Telomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; Telomerase Reverse Transcriptase; Telomerase Catalytic Subunit; Telomerase-associated protein 2; TERT_HUMAN.	WB	Human
	TERT Antibody (YA3439) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TERT.

HY-P81110

	TERT Antibody Telomerase catalytic subunit; EST2; hEST2; TCS1; Telomerase associated protein 2; Telomere Reverse Transcriptase; TP2; TRT; Telomerase Reverse Transcriptase; Telomerase Catalytic Subunit; Telomerase-associated protein 2; TERT_HUMAN.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	TERT Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TERT.

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Cat. No.	Product Name		Classification

HY-174537

Human TERT mRNA		mRNA
Human TERT mRNA encodes the human telomerase reverse transcriptase (TERT) protein, a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

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Telomerase Reverse Transcriptase

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
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