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Results for "

Thiourea

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

1

Fluorescent Dyes

3

Biochemical Assay Reagents

3

Peptides

2

Isotope-Labeled Compounds

2

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1526
    Thiacetazone

    Thioacetazone; Amithiozone

    		 Bacterial Antibiotic Infection
    Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL .
    Thiacetazone
  • HY-13769A
    TPT-260 Dihydrochloride
    2 Publications Verification

    NSC55712; TPU-260 Dihydrochloride

    		 Drug Derivative Amyloid-β Beta-secretase Cardiovascular Disease Neurological Disease Inflammation/Immunology
    TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
    TPT-260 Dihydrochloride
  • HY-136394
    Diafenthiuron
    2 Publications Verification

    		 Environmental Pollutants Mitochondrial Metabolism Oxidative Phosphorylation Parasite Others
    Diafenthiuron is a thiourea compound commonly used a broad-spectrum insecticide and acaricide. Diafenthiuron disturbs the insect respiratory system by inhibiting the oxidative phosphorylation and mitochondrial ATP synthesis .
    Diafenthiuron
  • HY-P5290
    HYNIC-PSMA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research . HYNIC-PSMA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-PSMA
  • HY-W015915
    Aminoiminomethanesulphinic acid

    Thiourea dioxide

    		 Biochemical Assay Reagents Others
    Aminoiminomethanesulphinic acid (Thiourea dioxide) is a biological material or organic compound that can be used in life science research .
    Aminoiminomethanesulphinic acid
  • HY-120781
    Fluorescein-thiourea-PEG4-azide

    		PROTAC Linkers Cancer
    Fluorescein-thiourea-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Fluorescein-thiourea-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fluorescein-thiourea-PEG4-azide
  • HY-130160
    Fluorescein-thiourea-PEG2-azide

    		PROTAC Linkers Cancer
    Fluorescein-thiourea-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Fluorescein-thiourea-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fluorescein-thiourea-PEG2-azide
  • HY-D1896
    Chloride Ionophore IV

    		Fluorescent Dye Others
    Chloride Ionophore IV is a thiourea type hydrogen bonding-based receptor. Chloride Ionophore IV is a chloride ionophore .
    Chloride Ionophore IV
  • HY-P5292A
    HYNIC-iPSMA TFA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-iPSMA TFA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA TFA has excellent specificity and sensitivity . HYNIC-iPSMA TFA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-iPSMA TFA
  • HY-136952
    p-SCN-Bn-HOPO

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    p-SCN-Bn-HOPO is a bifunctional chelator that forms stable octadentate complexes with Zr (IV) and 89Zr 4+ via four 1,2-hydroxypyridone groups. p-SCN-Bn-HOPO conjugates with antibodies through the formation of thiourea bonds with lysine residues, and enables efficient 89Zr radiolabeling under mild conditions. p-SCN-Bn-HOPO inhibits bone uptake of free radiometals, stabilizes radiometal-antibody conjugates, and achieves PET imaging with low background and enhanced tumor-to-organ contrast. p-SCN-Bn-HOPO can be used in breast cancer-related research .
    p-SCN-Bn-HOPO
  • HY-P5292
    HYNIC-iPSMA

    		Radionuclide-Drug Conjugates (RDCs) PSMA Cancer
    HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity . HYNIC-iPSMA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    HYNIC-iPSMA
  • HY-139174
    (S)-DO271

    		MAGL Inflammation/Immunology
    (S)-DO271 is a non-active control probe targeting ABHD12, and it has almost no inhibitory activity against ABHD12 (IC50 > 100 μM). (S)-DO271 does not cause the upregulation of inflammatory factors and has no cytotoxicity. (S)-DO271 is suitable as a negative control for validating the functional studies of ABHD12 .
    (S)-DO271
  • HY-169703
    SPA0355
    1 Publications Verification

    		 RANKL/RANK p38 MAPK Akt NF-κB Inflammation/Immunology
    SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .
    SPA0355
  • HY-144727
    Anti-inflammatory agent 11

    		Bacterial TNF Receptor Infection Inflammation/Immunology
    Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research .
    Anti-inflammatory agent 11
  • HY-140943
    Biotin-PEG7-thiourea

    		PROTAC Linkers Cancer
    Biotin-PEG7-thiourea is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Biotin-PEG7-thiourea
  • HY-13769
    TPT-260

    TPU260

    		 Drug Derivative Beta-secretase Amyloid-β Cardiovascular Disease Neurological Disease Inflammation/Immunology
    TPT-260 (TPU260), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease .
    TPT-260
  • HY-118711
    HI-346

    		HIV Reverse Transcriptase Infection
    HI-346 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) for HIV-1 with an IC50 value against the HIV-1 virus strain (HTLV-IIIB) of 3 nM. HI-346 is a vaginal bactericidal contraceptive agent, with its sperm-killing activity having an EC50 value of 42 μM. HI-346 shows no cytotoxicity to normal cells at effective concentrations. HI-346 can be used in anti-HIV-1 and contraceptive research .
    HI-346
  • HY-133061
    Fluorescein-thiourea-PEG6-acid

    		PROTAC Linkers Cancer
    Fluorescein-thiourea-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Fluorescein-thiourea-PEG6-acid
  • HY-114747
    1-(Adamantan-1-yl)-3-propylthiourea

    1-(1-Adamantyl)-3-propyl-2-Thiourea

    		 Others Infection
    1-(Adamantan-1-yl)-3-propylthiourea (1-(1-Adamantyl)-3-propyl-2-thiourea) is a viricide .
    1-(Adamantan-1-yl)-3-propylthiourea
  • HY-W015915R
    Aminoiminomethanesulphinic acid (Standard)

    Thiourea dioxide (Standard)

    		 Reference Standards Biochemical Assay Reagents Others
    Aminoiminomethanesulphinic acid (Thiourea dioxide) (Standard) is the analytical standard of Aminoiminomethanesulphinic acid. This product is intended for research and analytical applications. Aminoiminomethanesulphinic acid is a solid formaldehyde substitute with both electrophilic and reductive properties. Aminoiminomethanesulphinic acid is commonly used in bleaching processes in the textile industry .
    Aminoiminomethanesulphinic acid (Standard)
  • HY-131097
    Malachite green isothiocyanate

    		Fluorescent Dye Others
    Malachite green isothiocyanate is an amine-reactive probe that reacts with amines to give the corresponding thiourea. Malachite green isothiocyanate is a reagent that has been used for the measurement of concentration of protein .
    Malachite green isothiocyanate
  • HY-151356
    Antibacterial agent 122

    		Bacterial Infection
    Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies .
    Antibacterial agent 122
  • HY-W743390
    Propylene thiourea-d6

    4-Methylimidazolidine-2-thione-d6

    		 Isotope-Labeled Compounds Drug Metabolite Others
    4-Methylimidazolidine-2-thione-d6 (4-Methylimidazolidine-2-thione-d6) is deuterium labeled 4-Methylimidazolidine-2-thione. Propylene thiourea is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing .
    Propylene thiourea-d6
  • HY-W015871R
    Guanylthiourea (Standard)

    N-(Diaminomethylene)Thiourea (Standard)

    		 Reference Standards
    Guanylthiourea (Standard) is the analytical standard of Guanylthiourea. This product is intended for research and analytical applications.
    Guanylthiourea (Standard)
  • HY-144735
    Anti-inflammatory agent 14

    		Bacterial Infection Inflammation/Immunology
    Anti-inflammatory agent 14 (compound 28) is an anti-inflammatory agent, with a MIC50 of 2 μM for Mtb H37Rv .
    Anti-inflammatory agent 14
  • HY-136394R
    Diafenthiuron (Standard)

    		Oxidative Phosphorylation Parasite Mitochondrial Metabolism Reference Standards Others
    Diafenthiuron (Standard) is the analytical standard of Diafenthiuron. This product is intended for research and analytical applications. Diafenthiuron is a thiourea compound commonly used pesticide. Diafenthiuron inhibits mitochondrial functioning in insect pests .
    Diafenthiuron (Standard)
  • HY-122196
    TYT-1

    		Flavivirus Others
    TYT-1 is a sulfonamide-thiourea compound that has inhibitory activity against West Nile virus replication with a 50% effective concentration of 0.7 microM, blocking a post-entry, pre-assembly step of viral replication.
    TYT-1
  • HY-B1526R
    Thiacetazone (Standard)

    Thioacetazone (Standard); Amithiozone (Standard)

    		 Reference Standards Bacterial Antibiotic Infection
    Thiacetazone (Standard) is the analytical standard of Thiacetazone. This product is intended for research and analytical applications. Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].
    Thiacetazone (Standard)
  • HY-162572
    Bitipazone

    		Parasite Infection
    Bitipazone, diacetylbis(piperidinethyl)thiourea cysteine ester (I), has potent anticoccidial activity. Bitipazone showed significant efficacy and good tolerability in rabbits and turkeys, and in chronic toxicity tests, bitipazone was tolerated in turkeys at concentrations below 90 ppm in feed. Pharmacokinetic studies show that bitipazone is eliminated slowly from the blood and organs of these animal species .
    Bitipazone
  • HY-107063
    AHR-1911

    10-Undecen-1-yl-thiopseudourea iodide

    		 Histamine Receptor Cancer
    AHR-1911 (10-Undecen-1-yl-Thiopseudourea Iodide;Isothiuronium) is a thiourea-based anti-inflammatory and anti-tumor agent that has an improving effect on burned skin. AHR-1911 produces histamine-like effects when injected intradermally and may reduce arterial pressure in anesthetized dogs. AHR-1911 inhibits tumor growth and reduces microsomal and C-polysome protein synthesis .
    AHR-1911
  • HY-144737
    Anti-inflammatory agent 15

    		Bacterial TNF Receptor Infection Inflammation/Immunology
    Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research .
    Anti-inflammatory agent 15
  • HY-159945
    tau Protein/α-synuclein-IN-2

    		α-synuclein Neurological Disease
    Tau Protein/α-synuclein-IN-2 (Compound 14T) is a blood-brain barrier penetrating tau and α-syn inhibitor. Through its thiourea linker structure, Tau Protein/α-synuclein-IN-2 dose-dependently reduces α-syn oligomerization. In biosensor cells, Tau Protein/α-synuclein-IN-2 prevents the seeding effect of tau aggregation. In the M17D neuroblastoma model, Tau Protein/α-synuclein-IN-2 exhibits anti-inclusion effects. Additionally, Tau Protein/α-synuclein-IN-2 reduces Aβ plaque formation. Tau Protein/α-synuclein-IN-2 holds promise for Alzheimer's disease and Parkinson's disease research.
    tau Protein/α-synuclein-IN-2
  • HY-119202
    (S)-BMS-378806

    (S)-BMS-806

    		 HIV Infection
    (S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA .
    (S)-BMS-378806
  • HY-167919
    1-(1-Adamantyl)-3-butyl-2-thiourea

    		Drug Derivative Infection
    1-(1-Adamantyl)-3-butyl-2-thiourea is a compound with antiviral activity, demonstrating efficacy against various viral pathogens; 1-(1-Adamantyl)-3-butyl-2-thiourea serves as a potential therapeutic agent in the treatment of viral infections.
    1-(1-Adamantyl)-3-butyl-2-thiourea
  • HY-23331
    Propylene thiourea

    4-Methylimidazolidine-2-thione

    		 Drug Metabolite Others
    Propylene thiourea (4-Methylimidazolidine-2-thione) is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing .
    Propylene thiourea
  • HY-23331S
    Propylene thiourea-d3

    4-Methylimidazolidine-2-thione-d3

    		 Isotope-Labeled Compounds Drug Metabolite Others
    4-Methylimidazolidine-2-thione-d3 (4-Methylimidazolidine-2-thione-d3) is deuterium labeled 4-Methylimidazolidine-2-thione. Propylene thiourea is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing .
    Propylene thiourea-d3
  • HY-W281950
    2-(Carbamimidoylsulfanyl)acetic acid hydrochloride

    		Drug Derivative Metabolic Disease
    2-(Carbamimidoylsulfanyl)acetic acid hydrochloride is a thiourea compound and an Isothiourea derivative, with potential antidiabetic activity .
    2-(Carbamimidoylsulfanyl)acetic acid hydrochloride
  • HY-W100150
    N-((6-Methylpyridin-2-yl)carbamothioyl)benzamide

    		Biochemical Assay Reagents Cancer
    N-((6-Methylpyridin-2-yl) carbamothioyl) benzamide (Compound L3) is a thiourea ligand and monodentate ligand. The IC50 of N-((6-Methylpyridin-2-yl) carbamothioyl) benzamide in tested cell lines is > 100 μM. N-((6-Methylpyridin-2-yl) carbamothioyl) benzamide shows no activity against colorectal cancer cells and pancreatic cancer cells .
    N-((6-Methylpyridin-2-yl)carbamothioyl)benzamide

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