Antibacterial agent 122 

Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies^[1].

Antibacterial agent 122 (compound 15) (25-200 µM, 24 h) inhibits M. tuberculosis H37Rv with the MIC₅₀ value of 5.9 µM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC₅₀ value of 8.1µM^[1].
Antibacterial agent 122 (compound 15) (25-200 µM) acts on NO scavenging with an IC₅₀ value of 184.2 µM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 µM^[1].
Antibacterial agent 122 (compound 15) (0-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC₅₀ values of 28.4 µM and 47.9 µM, respectively^[1].
Antibacterial agent 122 (compound 15) (25-100 µM, 4 days) inhibits M. tuberculosis M299 with an MIC₅₀ value of 24.7 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

302.35

C₁₅H₁₄N₂O₃S

109310-99-8

O=C(O)C1=CC=C(NC(NCC2=CC=CC=C2)=S)C=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sanderson Dias Calixto, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.  [Content Brief]