Antibacterial agent 122
Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies.
For research use only. We do not sell to patients.
- CAS No.: 109310-99-8
- Formula: C15H14N2O3S
- Molecular Weight:302.35
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | CC50 |
196.7 μM
Compound: 15
|
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
|
[PMID: 34890996] |
| RAW264.7 | IC50 |
28.4 μM
Compound: 15
|
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
|
[PMID: 34890996] |
| RAW264.7 | IC50 |
47.9 μM
Compound: 15
|
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
|
[PMID: 34890996] |
| RAW264.7 | IC50 |
8.1 μM
Compound: 15
|
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
|
[PMID: 34890996] |
Antibacterial agent 122 (compound 15) (25-200 µM, 24 h) inhibits M. tuberculosis H37Rv with the MIC50 value of 5.9 µM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 8.1µM[1].
Antibacterial agent 122 (compound 15) (25-200 µM) acts on NO scavenging with an IC50 value of 184.2 µM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 µM[1].
Antibacterial agent 122 (compound 15) (0-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC50 values of 28.4 µM and 47.9 µM, respectively[1].
Antibacterial agent 122 (compound 15) (25-100 µM, 4 days) inhibits M. tuberculosis M299 with an MIC50 value of 24.7 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 109310-99-8
-
Molecular Weight 302.35
-
Formula C15H14N2O3S
-
SMILES
O=C(O)C1=CC=C(NC(NCC2=CC=CC=C2)=S)C=C1O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 122 Related Classifications
HY-151356 Related Classifications
Powered by Bioz