1. Anti-infection
  2. Bacterial
  3. Thiacetazone

Thiacetazone (Synonyms: Thioacetazone; Amithiozone)

Cat. No.: HY-B1526
Handling Instructions

Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL.

For research use only. We do not sell to patients.

Thiacetazone Chemical Structure

Thiacetazone Chemical Structure

CAS No. : 104-06-3

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5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
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Description

Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].

IC50 & Target

MIC: 0.1 μg/mL (Mycobacterium tuberculosis H37Rv)[1]

In Vitro

Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl[3].

In Vivo

The Km and Vmax values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat[2].

Molecular Weight

236.29

Formula

C₁₀H₁₂N₄OS

CAS No.

104-06-3

SMILES

CC(NC1=CC=C(/C=N/NC(N)=S)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ThiacetazoneThioacetazoneAmithiozoneBacterialAntitubercularthiourea-containingantibacterialorallyantibioticmonooxygenaseEthAInhibitorinhibitorinhibit

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