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Results for "

boronic acid inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (11) Beta-lactamase (6) Biochemical Assay Reagents (2) CXCR (1) Drug Intermediate (6) Estrogen Receptor/ERR (1) HPV (1) Lipase (1) Proteasome (2) Thrombin (2) Urease (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (1) Infection (11) Inflammation/Immunology (2)

Inhibitors & Agonists

Bibliotecas de Screening

Biochemical Assay Reagents

Targets Recommended: Serpin

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-19930

Vaborbactam Maximum Cited Publications 41 Publications Verification RPX7009	Beta-lactamase Bacterial	Infection
Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

HY-136072

Xeruborbactam disodium 5+ Cited Publications	Bacterial	Infection
Xeruborbactam disodium is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range .

HY-109124

Taniborbactam 15+ Cited Publications VNRX-5133	Beta-lactamase Bacterial	Infection
Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria .

HY-109124A

Taniborbactam hydrochloride 15+ Cited Publications VNRX-5133 hydrochloride	Beta-lactamase Bacterial	Infection
Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam hydrochloride has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria .

HY-111521

Meropenem-vaborbactam Carbavance	Antibiotic Bacterial Beta-lactamase	Infection
Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC₅₀ of 0.5 μg/mL and an MIC₉₀ of 8 μg/mL .

HY-W001242

1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester	Biochemical Assay Reagents Drug Intermediate	Others
1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a pharmaceutical intermediate used in the synthesis of naphthyl FXIa/PKa inhibitors .

HY-32951

2-Fluoropyridine-4-boronic acid	Drug Intermediate	Others
2-Fluoropyridine-4-boronic acid is a coupling reagent and chemical intermediate. 2-Fluoropyridine-4-boronic acid facilitates the synthesis of Rho kinase (ROCK) inhibitor Compound 37 .

HY-I0314

1H-Pyrazole-4-boronic acid pinacol ester	Drug Intermediate	Others
1H-Pyrazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of Mps1 kinase inhibitors .

HY-23524

HSL-IN-3 1 Publications Verification	Lipase	Others
HSL-IN-3, a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL) .

HY-136069

Xeruborbactam	Bacterial	Infection
Xeruborbactam is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam inhibits key serine and metallo beta-lactamases at a nano molar range .

HY-12927

SX-517	CXCR	Inflammation/Immunology
SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca ²⁺ flux (IC₅₀=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC₅₀=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model .

HY-32955

2-Chloropyridine-5-boronic acid	Bacterial	Infection
2-Chloropyridine-5-boronic acid is a mandelate racemase (MR) inhibitor with a K_i value of 8.5 μM against Pseudomonas putida MR .

HY-137144

Fulvestrant-3-boronic acid ZB716	Estrogen Receptor/ERR	Cancer
Fulvestrant-3-boronic acid is an orally active ERα inhibitor, which binds to ERα competitively (IC₅₀ = 4.1 nM) and effectively degrades ERα in breast cancer cells .

HY-W002734

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Drug Intermediate	Endocrinology
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .

HY-32952

2-Fluoropyridine-5-boronic acid 6-Fluoropyridine-3-boronic acid	Drug Intermediate	Others
2-Fluoropyridine-5-boronic acid (6-Fluoropyridine-3-boronic acid) is a drug intermediate that can be used in the synthesis of fatty acid amide hydrolase inhibitors and pyrethroid derivatives .

HY-78197

3,5-Dimethylisoxazole-4-boronic acid pinacol ester	Drug Intermediate	Others
3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of bromodomain inhibitors .

HY-136071

Xeruborbactam methoxy acetoxy methy ester	Beta-lactamase Bacterial	Infection
Xeruborbactam methoxy acetoxy methy ester is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 43 .

HY-136070

Xeruborbactam bis-acetoxy methyl ester	Beta-lactamase Bacterial	Infection
Xeruborbactam bis-acetoxy methyl ester is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 42 .

HY-W002463

3-Chlorophenyl boronic acid	Biochemical Assay Reagents	Others
3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

HY-161998

Urease-IN-16	Bacterial Urease	Others
Urease-IN-16 (compound 4e) is a urease inhibitor, with an IC₅₀ value of 132 μmol/L. Urease-IN-16 can coordinate with the nickel atom through the oxygen atoms of carbonyl or boronic acid groups. Urease-IN-16 shows great potential as an additive in the development of efficient fertilizers and medical applications .

HY-150766

KPC-2-IN-1	Bacterial	Infection
KPC-2-IN-1, boronic acid derivative, is a potent KPC-2 inhibitor with K_i of 0.032 μM. KPC-2-IN-1 enhances the activity of cefotaxime in KPC-2 expressing E. coli. KPC-2-IN-1 exhibits well tolerated in human HEK-293 cells, which can be used for the study of E. coli resistance to β-lactam antibiotics .

HY-19222

CVS-1123	Thrombin	Cardiovascular Disease
CVS-1123 is an orally active direct thrombin inhibitor. CVS-1123 inhibits in vitro platelet aggregation of γ-thrombin and prolongs activated partial thromboplastin time. CVS-1123 alters the thrombotic response to deep vessel wall damage in arterial and venous circulation. CVS-1123 can be used in antithrombotic studies

HY-142920

LMP7-IN-1	Proteasome	Inflammation/Immunology
LMP7-IN-1, a Boronic acid derivative, is a potent and selective immunoproteasome subunit LMP7 (β5i) inhibitor with an IC₅₀ of 1.83 nM (WO2021143923A1; compound 20) .

HY-149832

Anticancer agent 114	Proteasome	Cancer
Anticancer agent 114 is a potent and orally active *dipeptide boronic* acid ester proteasome** inhibitor with an IC₅₀ value of 2.2 nM. Anticancer agent 114 has antiproliferative activity against the RPMI-8226 cells. Anticancer agent 114 can be used in research of multiple myeloma .

HY-19220

S-18326	Thrombin	Cardiovascular Disease
S-18326 is an orally active direct thrombin inhibitor. S-18326 inhibits thrombus formation by reversibly and with high affinity binding to the active site of thrombin, directly preventing the conversion of fibrinogen to fibrin. S-18326 effectively prolongs various clotting times in human plasma. S-18326 has demonstrated antithrombotic efficacy in multiple animal models without causing thrombocytopenia. S-18326 can be used in research on thromboembolic diseases .

HY-W134304

Sodium metaborate		Others
Sodium metaborate is a borax derivative and boron source that serves as a stabilizer in textile processing and a corrosion inhibitor. Sodium metaborate acts as a precursor to sodium borohydride, a hydrogen storage medium. Sodium metaborate is used in the production of sodium perborate tetrahydrate .

HY-183322

Antiviral agent 83	HPV	Infection
Antiviral agent 83 is a boronic acid-modified Neocryptolepine (HY-E70250) derivative and is an anti-HPV agent. Antiviral agent 83 bind to the viral capsid protein and/or envelope protein, inducing conformational changes that effectively obstruct the interaction between the virus and host cell receptors. Antiviral agent 83 exhibits inhibitory activity against multiple high-risk HPV strains. Antiviral agent 83 inhibits HPV infection in vitro and in vaginal tract in vivo .

Cat. No.	Nombre del producto

HY-L908

Lead-like Covalent Screening Library	1,248 compounds
Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery. MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

Lead-like Covalent Screening Library

1,248 compounds

Small molecule covalent inhibitors, or irreversible inhibitors, are a type of inhibitors that exert their biological functions by irreversibly binding to target through covalent bonds. Compared with non-covalent inhibitors, covalent inhibitors have obvious advantages in bioactivity, such that covalent warheads can target rare residues of a particular target protein, thus leading to the development of highly selective inhibitors and achieving a more complete and continued target occupancy in living systems. In recent years, the distinct strengths of covalent inhibitors in overcoming drug resistance had been recognized. However, toxicity can be a real challenge related to this class of therapeutics due to their potential for off-target reactivity and has led to these drugs being disfavored as a drug class. The drug design and optimization of covalent inhibitors has become a hot spot in drug discovery.

MCE Lead-like Covalent Screening Library offers a valuable resource of 1,049 lead-like compounds with commonly used covalent warheads. These warheads, such as acrylamide, activated terminal alkyne, acyloxymethyl ketone, and boronic acid, are capable of reacting with specific amino acid residues, including cysteine, lysine, serine, and histidine. The inclusion of these reactive warheads in the library allows researchers to explore the potential of covalent inhibition, a powerful approach in drug discovery.

Cat. No.	Nombre del producto	Type

HY-W001242

1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester	Biochemical Assay Reagents
1-(Tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester is a pharmaceutical intermediate used in the synthesis of naphthyl FXIa/PKa inhibitors .

HY-32951

2-Fluoropyridine-4-boronic acid	Biochemical Assay Reagents
2-Fluoropyridine-4-boronic acid is a coupling reagent and chemical intermediate. 2-Fluoropyridine-4-boronic acid facilitates the synthesis of Rho kinase (ROCK) inhibitor Compound 37 .

HY-I0314

1H-Pyrazole-4-boronic acid pinacol ester	Biochemical Assay Reagents
1H-Pyrazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of Mps1 kinase inhibitors .

HY-32955

2-Chloropyridine-5-boronic acid	Biochemical Assay Reagents
2-Chloropyridine-5-boronic acid is a mandelate racemase (MR) inhibitor with a K_i value of 8.5 μM against Pseudomonas putida MR .

HY-W002734

(3-Hydroxyphenyl)boronic acid 3-Hydroxybenzeneboronic acid	Biochemical Assay Reagents
(3-Hydroxyphenyl)boronic acid (3-Hydroxybenzeneboronic acid) is a drug intermediate that can be used for the synthesis of 17β-hydroxysteroid dehydrogenase type 1 inhibitors .

HY-32952

2-Fluoropyridine-5-boronic acid 6-Fluoropyridine-3-boronic acid	Biochemical Assay Reagents
2-Fluoropyridine-5-boronic acid (6-Fluoropyridine-3-boronic acid) is a drug intermediate that can be used in the synthesis of fatty acid amide hydrolase inhibitors and pyrethroid derivatives .

HY-78197

3,5-Dimethylisoxazole-4-boronic acid pinacol ester	Biochemical Assay Reagents
3,5-Dimethylisoxazole-4-boronic acid pinacol ester is a drug intermediate that can be used for the synthesis of bromodomain inhibitors .

HY-W002463

3-Chlorophenyl boronic acid	Biochemical Assay Reagents
3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

3-Chlorophenyl boronic acid

Biochemical Assay Reagents

3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. 3-Chlorophenylboronic acid is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors among others. 3-Chlorophenyl boronic acid can affect cell migration. 3-Chlorophenyl boronic acid can be used to study wound healing .

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