Fulvestrant-3-boronic acid
Based on 1 Customer Validation
Fulvestrant-3-boronic acid is an orally active ERα inhibitor, which binds to ERα competitively (IC50 = 4.1 nM) and effectively degrades ERα in breast cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.7%
- CAS No.: 1853279-29-4
- Formula: C32H48BF5O4S
- Molecular Weight:634.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.0032 μM
Compound: 5; ZB716
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Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
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[PMID: 27529700] |
| MCF7 | IC50 |
0.069 μM
Compound: 5; ZB716
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Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
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[PMID: 27529700] |
| T47D | IC50 |
0.0061 μM
Compound: 5; ZB716
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Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
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[PMID: 27529700] |
| T47D | IC50 |
0.037 μM
Compound: 5; ZB716
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Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
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[PMID: 27529700] |
| T47D | IC50 |
12.7 nM
Compound: 5; ZB716
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Downregulation of ER-alpha expression in human tamoxifen-resistant T47D cells over-expressing PKC-alpha measured after 5 days by Western blot analysis
Downregulation of ER-alpha expression in human tamoxifen-resistant T47D cells over-expressing PKC-alpha measured after 5 days by Western blot analysis
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[PMID: 27529700] |
| T47D | IC50 |
7.8 nM
Compound: 5; ZB716
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Downregulation of ER-alpha expression in human T47D cells measured after 5 days by Western blot analysis
Downregulation of ER-alpha expression in human T47D cells measured after 5 days by Western blot analysis
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[PMID: 27529700] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1853279-29-4
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Appearance Solid
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Molecular Weight 634.59
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Formula C32H48BF5O4S
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Color White to off-white
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SMILES
FC(F)(F)C(F)(F)CCCS(CCCCCCCCC[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@@H]3O)C)([H])C4=CC=C(B(O)O)C=C4C1)=O
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Synonyms
ZB716
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (563 KB)
- English - EN (563 KB)
- Français - FR (563 KB)
- Deutsch - DE (563 KB)
- Norwegian - NO (563 KB)
- Español - ES (563 KB)
- Swedish - SV (563 KB)
- Italian - IT (563 KB)
- Korean - KR (563 KB)
- Portuguese - PT (563 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fulvestrant-3-boronic acid Related Classifications
HY-137144 Related Classifications
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