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Results for "

bypass

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) AMPK (1) Amyloid-β (1) Apoptosis (4) Bcl-2 Family (1) Biochemical Assay Reagents (1) ByeTAC (1) Cadherin (2) Caspase (1) Checkpoint Kinase (Chk) (1) Claudin (2) DNA/RNA Synthesis (2) Drug Isomer (1) Dystrophin (1) EGFR (1) Endogenous Metabolite (2) Epigenetic Reader Domain (1) Guanylate Cyclase (1) Histone Demethylase (1) NO Synthase (1) PD-1/PD-L1 (1) PI3K (2) PKC (2) PROTAC Linkers (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Ser/Thr Protease (1) Tau Protein (1) Tie (2) TLK (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (5) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (2)

By Targets:

Akt (3)

AMPK (1)

Amyloid-β (1)

Apoptosis (4)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

ByeTAC (1)

Cadherin (2)

Caspase (1)

Checkpoint Kinase (Chk) (1)

Claudin (2)

DNA/RNA Synthesis (2)

Drug Isomer (1)

Dystrophin (1)

EGFR (1)

Endogenous Metabolite (2)

Epigenetic Reader Domain (1)

Guanylate Cyclase (1)

Histone Demethylase (1)

NO Synthase (1)

PD-1/PD-L1 (1)

PI3K (2)

PKC (2)

PROTAC Linkers (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

Ser/Thr Protease (1)

Tau Protein (1)

Tie (2)

TLK (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (5)

Infection (2)

Inflammation/Immunology (5)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121320

Raptinal Maximum Cited Publications 10 Publications Verification	Caspase Apoptosis	Cancer
Raptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9 .

HY-111095B

D-(-)-Lactic acid sodium (R)-2-Hydroxypropionic acid sodium	Endogenous Metabolite Drug Isomer	Neurological Disease Metabolic Disease
D-(-)-Lactic acid ((R)-2-Hydroxypropionic acid) sodium is an orally active, toxic optical isomer of Lactic acid (HY-B2227), mainly derived from overproduction by intestinal bacteria or exogenous intake. D-(-)-Lactic acid sodium can induce intoxication, characterized by severe metabolic acidosis accompanied by neurological symptoms .

HY-Y1139

Pimelic acid 2 Publications Verification Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid	Endogenous Metabolite PROTAC Linkers	Metabolic Disease
Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .

HY-P10580

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

HY-W010380

Methyl succinate	AMPK Apoptosis	Metabolic Disease
Methyl succinate is a mitochondrial complex II substrate. Methyl succinate can bypass the inhibition of complex I by Metformin (HY-B0627), restore mitochondrial electron transfer, and reduce AMPK phosphorylation. Methyl succinate is capable of protecting MIN6 β-cells and primary rat β-cells from biguanide-induced toxicity and apoptosis in vitro. Methyl succinate can be used in the research of diseases such as diabetes mellitus .

HY-P10580A

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream PI3K/Akt and eNOS pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

HY-W140900

Sodium (S)-3-amino-3-carboxypropanoate hydrate Sodium L-aspartate monohydrate	Biochemical Assay Reagents	Cardiovascular Disease
Sodium (S)-3-amino-3-carboxypropanoate hydrate is a biochemical assay reagent, which is utilized in bypass surgery as part of the cardioplegia solution .

HY-123359

RTC14	DNA/RNA Synthesis Dystrophin	Others
RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene .

HY-W841438

Lithium orotate	Amyloid-β Tau Protein	Neurological Disease
Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease .

HY-176071

TEC 4	ByeTAC Epigenetic Reader Domain	Cancer
TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC₅₀ of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad (HY-78695); Blue: Rpn-13 ligand (HY-159808); Black: linker (HY-W008352) .

HY-149213

LSD1/TLK1-IN-1 J54; J3-54	Histone Demethylase TLK Apoptosis PD-1/PD-L1	Cancer
LSD1/TLK1-IN-1 is an orally active LSD1, TLK1, TLK2, TTK inhibitor with an LSD1 IC₅₀ of 0.247 μM. LSD1/TLK1-IN-1 suppresses phosphorylation of Nek1 at T141 and Rad9 at S328, abrogates the TLK1>Nek1>ATR>Chk1 axis, protects H3K4me1/2 from demethylation, and does not affect LSD2, MAO-A, or MAO-B. LSD1/TLK1-IN-1 induces apoptosis, bypasses cell-cycle arrest, suppresses tumor growth, downregulates PD-L1 expression, enhances T-cell killing response, inhibits gastric cancer cell proliferation. LSD1/TLK1-IN-1 can be used for the research of prostate cancer and gastric cancer .

HY-B1245R

Salsalate (Standard) Salicylsalicylic acid (Standard); Disalicylic acid (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Inflammation/Immunology
Salsalate (Standard) is the analytical standard of Salsalate. This product is intended for research and analytical applications. Salsalate, a non-acetylated salicylate, is an effective antirheumatic agent that bypasses gastric absorption and also avoids cyclooxygenase inhibition. Salsalate has anti-inflammatory activity and reduces glucose levels, insulin resistance, and cytokine expression. Salsalate can be used in the research of type 2 diabetes .

HY-107000

RIG 200	Guanylate Cyclase NO Synthase	Cardiovascular Disease
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor. RIG 200 releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells, increasing cGMP levels, and leading to vasodilation. RIG 200 significantly inhibits Collagen (HY-NP003)-induced platelet aggregation in platelet-rich plasma (PRP). RIG 200 may be used in research on antithrombus .

HY-P5888

PKCε inhibitor peptide,myristoylated Myr‐PKCɛ-	PKC	Inflammation/Immunology
PKCε inhibitor peptide,myristoylated (Myr-PKCε-) is a cell permeable myristic acid conjugated PKC peptide inhibitor that attenuates NO release in cultured human umbilical vein endothelial cells (HUVECs) .

HY-P5877

ɛPKC(85–92),Myristoylated	PKC	Inflammation/Immunology
PKC(85–92),Myristoylated is a cell permeable myristic acid conjugated PKC peptide activator that enhances NO release in cultured human umbilical vein endothelial cells (HUVECs) .

HY-180357

Graviquinone	Checkpoint Kinase (Chk) Reactive Oxygen Species (ROS) DNA/RNA Synthesis	Cancer
Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of bypassing ABCB1-mediated multidrug resistance, selectively damaging cancer cell DNA, and regulating the DNA damage response. Graviquinone can also enhance cytotoxicity by increasing ROS levels in cancer cells. Graviquinone can be used for cancer research .

HY-182914

NGI-189	EGFR Akt Bcl-2 Family Apoptosis	Cancer
NGI‑189 is a selective OST‑A inhibitor. NGI‑189 inhibits the STT3A catalytic subunit of the OST complex and reduces N‑glycosylation of target glycoproteins. NGI‑189 blocks oncogenic and bypass signaling, reduces phosphorylation of EGFR, AKT, p70S6K and S6RP, and induces cell cycle arrest and apoptosis. NGI‑189 markedly suppresses tumor growth and induces tumor regression in non‑small cell lung cancer (NSCLC) xenograft models. NGI‑189 can be used for the research of EGFR‑mutant non‑small cell lung cancer .

HY-182406

CU-2010	Ser/Thr Protease	Cardiovascular Disease
CU-2010 is a Serine protease inhibitor. In canine models, CU-2010 reduces blood loss after cardiac surgery in a dose-dependent manner and improves post-ischemic recovery .

Sodium (S)-3-amino-3-carboxypropanoate hydrate Sodium L-aspartate monohydrate	Biochemical Assay Reagents
Sodium (S)-3-amino-3-carboxypropanoate hydrate is a biochemical assay reagent, which is utilized in bypass surgery as part of the cardioplegia solution .

Cat. No.	Product Name	Target	Research Area