TEC 4
Based on 1 Customer Validation
TEC 4 is a ByeTAC (Bypassing E-Ligase-Targeting Chimera) BRD4 degrader, with 33% BRD4 remaining at 500 nM in Ramos B-cells. TEC 4 shows toxicity for Ramos B-cells, with an IC50 of 30.5 nM. ByeTACs directly recruits a protein to the proteasome via interactions with Rpn-13 for degradation. Pink: BRD4 lignad (HY-78695); Blue: Rpn-13 ligand (HY-159808); Black: linker (HY-W008352).
For research use only. We do not sell to patients.
- Purity: 99.57%
- Formula: C48H51BrCl2N10O6S2
- Molecular Weight:1078.92
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 1078.92
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Formula C48H51BrCl2N10O6S2
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Color White to off-white
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SMILES
BrC1=CC=C(CC2=NN=C(N2N=C3C4=CC=C(C=C4)Cl)SC3CC(NCCOCCOCCOCCOCCNC(C[C@H]5C6=NN=C(N6C7=C(C(C8=CC=C(C=C8)Cl)=N5)C(C)=C(S7)C)C)=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (92.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9269 mL | 4.6343 mL | 9.2685 mL | 23.1713 mL |
| 5 mM | 0.1854 mL | 0.9269 mL | 1.8537 mL | 4.6343 mL | |
| 10 mM | 0.0927 mL | 0.4634 mL | 0.9269 mL | 2.3171 mL | |
| 15 mM | 0.0618 mL | 0.3090 mL | 0.6179 mL | 1.5448 mL | |
| 20 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL | 1.1586 mL | |
| 25 mM | 0.0371 mL | 0.1854 mL | 0.3707 mL | 0.9269 mL | |
| 30 mM | 0.0309 mL | 0.1545 mL | 0.3090 mL | 0.7724 mL | |
| 40 mM | 0.0232 mL | 0.1159 mL | 0.2317 mL | 0.5793 mL | |
| 50 mM | 0.0185 mL | 0.0927 mL | 0.1854 mL | 0.4634 mL | |
| 60 mM | 0.0154 mL | 0.0772 mL | 0.1545 mL | 0.3862 mL | |
| 80 mM | 0.0116 mL | 0.0579 mL | 0.1159 mL | 0.2896 mL |
TEC 4 Related Classifications
HY-176071 Related Classifications
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