Vasculotide TFA

Vasculotide (200 ng per rat; intravenous injection; single dose) TFA preserves microcirculatory perfusion and reduces pulmonary vascular leakage in male Wistar rats during and after cardiopulmonary bypass, without altering the endogenous angiopoietin/Tie2 system^[1].
Vasculotide (10 μg/kg; intraperitoneal injection; administered 24 h and 1.5 h prior to irradiation, followed by once every other day for 28 consecutive days) TFA reduces acute cutaneous radiation injury in mice, as evidenced by a 43% reduction in the total area of severe desquamation wounds, alleviated inflammatory responses, and improved wound healing^[2].
Vasculotide (10 μg/kg; i.p.; pre-irradiation only, continuous administration, post-irradiation only; total 26 days) TFA reduces acute cutaneous radiation injury in mice exposed to 35 Gy irradiation when administered via all tested regimens (pre-irradiation, continuous administration, post-irradiation) TFA, among which the post-irradiation regimen significantly decreases the overall skin injury score by 28%^[2].
Vasculotide (250 ng; intraperitoneal injection; once every 48 hours; for 3 months) TFA reduces the superharmonic threshold pressure for focused ultrasound (FUS)-induced blood-brain barrier (BBB) permeability by 21-29% in TgCRND8 mice and accelerates BBB repair, with an 87% BBB closure rate observed 20 hours after FUS treatment in this Alzheimer's disease model^[3].
Adjuvant therapy with Vasculotide (500 ng; intravenous injection; 2 administrations) TFA combined with Ampicillin (HY-B0522) significantly reduces pulmonary permeability, ventilator-induced lung injury (VILI)-related histological damage and edema formation in mice with mechanically ventilated Streptococcus pneumoniae pneumonia, without affecting immune responses or bacterial loads^[4].