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Results for "

cAMP assay

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Aminotransferases (Transaminases) (1) Amyloid-β (1) Apelin Receptor (APJ) (2) Arrestin (3) CGRP Receptor (2) Dopamine Receptor (2) Endogenous Metabolite (1) Free Fatty Acid Receptor (1) FXR (1) G protein-coupled Bile Acid Receptor 1 (1) GLP Receptor (1) GPR6 (1) GPR84 (1) GPR88 (5) Melanocortin Receptor (2) Orphan Nuclear Receptor (1) PACAP Receptor (1) Prostaglandin Receptor (2) Reference Standards (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (4) Metabolic Disease (6) Neurological Disease (15)

By Targets:

Adenylate Cyclase (2)

Aminotransferases (Transaminases) (1)

Amyloid-β (1)

Apelin Receptor (APJ) (2)

Arrestin (3)

CGRP Receptor (2)

Dopamine Receptor (2)

Endogenous Metabolite (1)

Free Fatty Acid Receptor (1)

FXR (1)

G protein-coupled Bile Acid Receptor 1 (1)

GLP Receptor (1)

GPR6 (1)

GPR84 (1)

GPR88 (5)

Melanocortin Receptor (2)

Orphan Nuclear Receptor (1)

PACAP Receptor (1)

Prostaglandin Receptor (2)

Reference Standards (2)

By Research Areas:

Cancer (1)

Cardiovascular Disease (1)

Inflammation/Immunology (4)

Metabolic Disease (6)

Neurological Disease (15)

Inhibitors & Agonists

Peptides

Targets Recommended: Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P6292A

KS-133 TFA	PACAP Receptor	Neurological Disease Inflammation/Immunology Cancer
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC₅₀ values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation .

HY-160734

Aleniglipron GSBR-1290	GLP Receptor	Metabolic Disease
Aleniglipron (GSBR-1290) is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist, with an EC₅₀ value of less than 0.1 nM in HDB cell lines in cAMP stimulation assays. Aleniglipron selectively activates the Gαs-cAMP signaling pathway of GLP-1R without β-arrestin recruitment. Aleniglipron induces insulin release, promotes glucose clearance, reduces food intake and decreases body weight. Aleniglipron is applicable to research related to type 2 diabetes and obesity .

HY-103254

ML221 Maximum Cited Publications 9 Publications Verification	Arrestin Apelin Receptor (APJ)	Neurological Disease
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC₅₀s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC₈₀ of 10 nM in both assays.

HY-103194

KH7 5+ Cited Publications	Adenylate Cyclase	Others
KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sAC_t protein and heterologously expressed sACt in cellular assays . KH7 is also a *cAMP* inhibitor .

HY-153660

Bivamelagon MC-4R Agonist 2	Melanocortin Receptor	Metabolic Disease
Bivamelagon (MC-4R Agonist 2) is an orally active MC4R agonist with EC₅₀ values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a K_i of 65 nM. Bivamelagon can be used for the research of diseases such as obesity and diabetes .

HY-112612A

RTI-13951-33 hydrochloride 2 Publications Verification	GPR88	Neurological Disease
RTI-13951-33 hydrochloride is a potent, selective, and brain-penetrant GPR88 agonist, with an EC₅₀ of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 hydrochloride reduces alcohol reinforcement and intake behaviors in rats .

HY-167856

RTI-122	GPR88	Neurological Disease
RTI-122 is a selective, blood-brain barrier-permeable GPR88 agonist (cAMP EC₅₀=11 nM), with EC₅₀ values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([ ³⁵S]GTPγS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 significantly attenuates Binge-like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 exhibits metabolic stability in mice (T_1/2=5.8 h) and can be used to investigate alcohol use disorder .

HY-176293

EP2 receptor antagonist-3	Prostaglandin Receptor Amyloid-β	Neurological Disease
EP2 receptor antagonist-3 is a selective EP2 receptor antagonist (IC₅₀: 8 nM in hEP2 SPA assay, 50 nM in hEP2 cAMP assay). EP2 receptor antagonist-3 increases the macrophage-mediated clearance of Amyloid-β plaques. EP2 receptor antagonist-3 can be used for the study of alzheimer’s diseases .

HY-118941

BAY 73-1449	Prostaglandin Receptor	Cardiovascular Disease
BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC₅₀ of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure .

HY-119486A

(Rac)-Tavapadon (Rac)-PF-06649751; (Rac)-CVL-751	Dopamine Receptor Arrestin	Neurological Disease
(Rac)-Tavapadon ((Rac)-PF-06649751) is a potent and selective noncatechol dopamine D1 receptor agonist. (Rac)-Tavapadon displays potent full agonism in the GS activation assay as well as partial agonism in the β-arrestin2 recruitment assay (GS-cAMP, EC₅₀=0.8 nM; β-arrestin2, EC₅₀=68 nM). (Rac)-Tavapadon has antiparkinsonian activity .

HY-169792

HPG1860	FXR Aminotransferases (Transaminases)	Metabolic Disease Inflammation/Immunology
HPG1860 is an orally active, highly selective and potent FXR agonist, with an EC₅₀ of 18 nM (FXR-luciferase reporter assay). HPG1860 has EC₅₀ values >30.0 μM for TGR5 and 13 other related nuclear receptors (cAMP biological assay). HPG1860 can be used for the research of non-alcoholic steatohepatitis (NASH) .

HY-156772

GPR88 agonist 2	GPR88	Others Neurological Disease
GPR88 agonist 2 (compound 53) is a potent and brain-penetrantGPR88 agonist with an EC₅₀ value of 14 µM in GPR88 cAMP functional assay .

HY-179471

PSB-17365	GPR84	Inflammation/Immunology
PSB-17365 is a potent GPR84 agonist with EC₅₀ values of 2.5 nM and 100 nM in a cAMP accumulation assay and a β-arrestin 2 recruitment assay, respectively .

HY-153660A

Bivamelagon hydrochloride MC-4R Agonist 2 hydrochloride	Melanocortin Receptor	Metabolic Disease
Bivamelagon (MC-4R Agonist 2) hydrochloride is an orally active and BBB-penetrable MC4R agonist with EC₅₀ values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a K_i of 65 nM. Bivamelagon hydrochloride can be used for the research of diseases such as obesity and diabetes .

HY-112612

RTI-13951-33	GPR88	Neurological Disease
RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC₅₀ of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats .

HY-P4863

Biotinyl-Amylin (human)	CGRP Receptor	Neurological Disease Metabolic Disease
Biotinyl-Amylin (human) is a biotin-labeled derivative of Amylin, amide, human (HY-P1070). Biotinyl-Amylin (human) acts as a competitive agonist for the Calcitonin Receptor (CTR) and for the Amylin receptors (AMY₁, AMY₂, and AMY₃) formed by the association of CTR with RAMP1/2/3. By mimicking endogenous human amylin, Biotinyl-Amylin (human) binds to and activates CTR and AMY receptors, thereby initiating downstream signaling pathways involving cAMP, CREB, and ERK1/2, while retaining high-affinity receptor binding and activation capabilities. Biotinyl-Amylin (human) is primarily utilized in studies investigating the metabolic regulatory mechanisms underlying obesity and diabetes; it is also applicable to pharmacological research, receptor localization studies, and ligand-binding assays related to Amylin receptors in the context of Alzheimer's disease .

HY-161817

TGR5 agonist 5	G protein-coupled Bile Acid Receptor 1	Others
TGR5 agonist 5 (compound K91) is a potent agonist of TGR5, with EC₅₀s of 19 μM and 30 μM in CRE-Luciferase assay anf cAMP accumulation assay, respectively .

HY-120879

PF2562	Dopamine Receptor	Neurological Disease
PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a K_i of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC₅₀ of 568 nM in HTRF assay .

HY-131844

6-Bnz-5'-AMP N6-Benzoyladenosine-5'-O-monophosphate	Endogenous Metabolite	Others
6-Bnz-5'-AMP is a lipophilic analogue of adenosine-5'-O-monophosphate and a potential metabolite of N ⁶-Benzoyl-cAMP. 6-Bnz-5'-AMP exhibits some cytokinin activity in tobacco and soybean tissue culture assays .

HY-171069

FFA2 agonist-1	Free Fatty Acid Receptor	Metabolic Disease
FFA2 agonist-1 (Compound 4) is the agonist for Free fatty acid receptor 2 (FFA2/GPR43) with an EC₅₀ of 81 nM. FFA2 agonist-1 exhibits activity in β-arrestin-2 recruitment assay and cAMP inhibition assay with EC₅₀ of 1.2 μM and 0.53 μM. FFA2 agonist-1 leads to appetite regulating peptide YY (PYY) mucosal responses, inhibits the fat accumulation, intestinal functions and food intake, and can be used for obesity research .

HY-159920

PSB-22269	Orphan Nuclear Receptor	Neurological Disease Inflammation/Immunology
PSB-22269 is a GPR17 antagonist with a K_i value of 8.91 nM. PSB-22269 further demonstrated significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies revealed that the binding site of PSB-22269 contains positively charged arginine residues and a hydrophobic pocket. PSB-22269 provides a strategy to promote remyelination and holds promise for research in the field of multiple sclerosis .

HY-103254R

ML221 (Standard)	Arrestin Apelin Receptor (APJ) Reference Standards	Neurological Disease
ML221 (Standard) is the analytical standard of ML221 (HY-103254). This product is intended for research and analytical applications. ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC₅₀s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.

HY-103194R

KH7 (Standard)	Reference Standards Adenylate Cyclase	Others
KH7 (Standard) is the analytical standard of KH7 (HY-103194). This product is intended for research and analytical applications. KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays . KH7 is also a cAMP inhibitor .

HY-167856A

RTI-122 dihydrochloride	GPR88	Neurological Disease
RTI-122 dihydrochloride is a selective, blood-brain barrier-permeable GPR88 agonist (cAMP EC₅₀=11 nM), with EC₅₀ values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([ ³⁵S]GTPγS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 dihydrochloride significantly attenuates Binge-like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 dihydrochloride blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 dihydrochloride exhibits metabolic stability in mice (T_1/2=5.8 h) and can be used to investigate alcohol use disorder .

HY-183180

CGRP antagonist-8	CGRP Receptor	Neurological Disease
CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine .

HY-182011

GPR6 inverse agonist 2	GPR6	Neurological Disease
GPR6 inverse agonist 2 (Compound 575) is a selective GPR6 inverse agonist, with IC₅₀ values of < 0.1 μM and 1~30 μM against GPR6 and GPR3, respectively. GPR6 inverse agonist 2 exhibits preliminary cardiac safety, with an IC₅₀ of 21.71 μM for hERG. GPR6 inverse agonist 2 can be used in the research of movement disorders such as Parkinson's disease .

Cat. No.	Product Name	Target	Research Area

HY-P6292A

KS-133 TFA	PACAP Receptor	Neurological Disease Inflammation/Immunology Cancer
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2) with IC₅₀ values for Ca influx measurement and cAMP measurement of 24.8 nM and 500 nM, respectively. KS-133 TFA reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. KS-133 TFA can be used for research on schizophrenia and cancer immune regulation .

HY-P4863

Biotinyl-Amylin (human)	CGRP Receptor	Neurological Disease Metabolic Disease
Biotinyl-Amylin (human) is a biotin-labeled derivative of Amylin, amide, human (HY-P1070). Biotinyl-Amylin (human) acts as a competitive agonist for the Calcitonin Receptor (CTR) and for the Amylin receptors (AMY₁, AMY₂, and AMY₃) formed by the association of CTR with RAMP1/2/3. By mimicking endogenous human amylin, Biotinyl-Amylin (human) binds to and activates CTR and AMY receptors, thereby initiating downstream signaling pathways involving cAMP, CREB, and ERK1/2, while retaining high-affinity receptor binding and activation capabilities. Biotinyl-Amylin (human) is primarily utilized in studies investigating the metabolic regulatory mechanisms underlying obesity and diabetes; it is also applicable to pharmacological research, receptor localization studies, and ligand-binding assays related to Amylin receptors in the context of Alzheimer's disease .

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