1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. BAY 73-1449

BAY 73-1449 

Cat. No.: HY-118941
Handling Instructions

BAY 73-1449 is a selective antagonist of prostacyclin IP receptor, with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure.

For research use only. We do not sell to patients.

BAY 73-1449 Chemical Structure

BAY 73-1449 Chemical Structure

CAS No. : 693790-96-4

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Description

BAY 73-1449 is a selective antagonist of prostacyclin IP receptor, with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1].

IC50 & Target[1]

IP Receptor

<0.1 nM (IC50)

In Vivo

BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats[1].
BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats[1].
BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats[1].

Animal Model: Male Wistar rats (250-350 g) are ligated portal vein[1]
Dosage: 0.1, 1 mg/kg
Administration: A single i.v.
Result: Significantly reduced shunt flow without affecting mesenteric flow.
Molecular Weight

425.48

Formula

C₂₆H₂₃N₃O₃

CAS No.

693790-96-4

SMILES

O=C(O)[[email protected]@H](CC1=CC=CC=C1)NC2=NC=NC(C3=CC=C(OCC4=CC=CC=C4)C=C3)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BAY 73-1449Prostaglandin ReceptorprostacyclinIPlowerbloodpressure,mesentericinflowsplenicshuntvesseloutflowporto-systemicportalInhibitorinhibitorinhibit

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BAY 73-1449
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