1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. PF2562

PF2562 

Cat. No.: HY-120879
Handling Instructions

PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay.

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PF2562 Chemical Structure

PF2562 Chemical Structure

CAS No. : 1609258-91-4

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Description

PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a Ki of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC50 of 568 nM in HTRF assay[1].

IC50 & Target

EC50: 568 nM (human D1 cAMP)[1]
Ki: 113 nM (human D1 receptor)[1]

In Vitro

Dopamine acts upon neurons through two families of dopamine receptors, D1-like receptors (D1Rs) and D2-like receptors (D2Rs). The D1-like receptor family consists of D1 and D5 receptors which are expressed in many regions of the brain. Dopamine D1 receptors are implicated in numerous neuropharmacological and neurobiological functions[1].

Molecular Weight

331.37

Formula

C₁₉H₁₇N₅O

CAS No.

1609258-91-4

SMILES

CC1=CC(OC2=NC=CC3=C2C=NN3)=CC=C1C4=C(N=CN=C4C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

PF2562PF 2562PF-2562Dopamine ReceptorAlzheimerSchizophreniaParkinsondiseaseInhibitorinhibitorinhibit

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PF2562
Cat. No.:
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