Bivamelagon hydrochloride
Bivamelagon (MC-4R Agonist 2) hydrochloride is an orally active and BBB-penetrable MC4R agonist with EC50 values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a Ki of 65 nM. Bivamelagon hydrochloride can be used for the research of diseases such as obesity and diabetes.
For research use only. We do not sell to patients.
- CAS No.: 2641595-55-1
- Formula: C35H54Cl2N4O4
- Molecular Weight:665.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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MC4R 65 nM (Ki) |
| Route | Dose (mg/kg) | Cmax (ng/mL) | AUCinf (ng•hr/mL) | t1/2 (hr) | |
| Plasma | p.o. | 10 | 232.3 | 2067.0 | 3.9 |
| Brain | p.o. | 10 | 49.1 | 1495.3 | 19.0 |