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Cat. No.: HY-183180

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CGRP antagonist-8

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine.

For research use only. We do not sell to patients.

CAS No.: 1610413-85-8
Formula: C₄₀H₄₇N₉O₅S
Molecular Weight:765.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGRP antagonist-8 Chemical Structure

CAS No.: 1610413-85-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SK-N-MC	EC₅₀	100 nM Compound: 8	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	[PMID: 24794104]

In Vitro

CGRP antagonist-8 (Compound 8) potently inhibits CGRP receptor binding in SK-N-MC cell membrane tissue with an IC₅₀ of 2.7 nM^[1].
CGRP antagonist-8 acts as a CGRP receptor antagonist in SK-N-MC cells, with an EC₅₀ of 100 nM in the cAMP functional assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1610413-85-8
Molecular Weight 765.92
Formula C₄₀H₄₇N₉O₅S
SMILES

O=C1N(C2CCN(CC2)C(N[C@@H](C(N[C@@H](CCCCN)C(N3CCN(C4=CC=NC=C4)CC3)=O)=O)CC5=CC6=CC=CC=C6S5)=O)C(NC7=CC=CC=C71)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dasgupta B, et al. Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist. Bioorg Med Chem Lett. 2014;24(12):2744-2748. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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