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United States

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製品番号: HY-159920

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PSB-22269

PSB-22269 is a competitive GPR17 antagonist. PSB-22269 can be used in research on multiple sclerosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₆H₂₁NO₆
分子量:443.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PSB-22269 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PSB-22269 is a competitive GPR17 antagonist. PSB-22269 can be used in research on multiple sclerosis^[1]^[2]^[3].

体外実験

PSB-22269 (1 h at room temperature) binds GPR17 in CHO-FITR-hGPR17 membrane radioligand binding assays with pK_i 8.05 (K_i 8.91 nM)^[1].
PSB-22269 (30 min) inhibits GPR17-induced calcium mobilization in CHO-FITR-hGPR17 cells with pIC₅₀ 7.0^[1].
PSB-22269 (0-1000 nM; 30 min) competitively inhibits GPR17-mediated calcium mobilization in 1321N1 astrocytoma cells with pIC₅₀ 6.90 and pK_B 7.46^[1].
PSB-22269 (20 min) inhibits GPR17 agonist-induced Gα_i2 activation in HEK293 cells with pIC₅₀ 6.31^[1].
PSB-22269 binds hGPR17 in the cell-free [³H]PSB-12150 binding assay using CHO-FITR cell membranes, with the reported overall IC₅₀ range of 0.0089-0.13 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 443.45
分子式 C₂₆H₂₁NO₆
SMILES

COC1=CC(C(O)=O)=C(NC(C2=CC=C(C3=C(C4=CC=CC(OC)=C4)C=CC=C3)O2)=O)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Boshta NM, et al. Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17. Journal of medicinal chemistry. 2024 Nov 14;67(21):19365-19394. [Content Brief]

[2]. Lewash M, et al. GPR17 - orphan G protein-coupled receptor with therapeutic potential. Trends in pharmacological sciences. 2025 Jul;46(7):610-628.

[3]. Lewash M. Ligand binding, activation, and stabilization of the orphan G protein-coupled receptor GPR17[D]. Universitäts-und Landesbibliothek Bonn, 2026.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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