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cdk5+inhibitor

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By Targets:	17β-HSD (1) Amyloid-β (2) CDK (15) DNA/RNA Synthesis (1) Drug Isomer (1) E1/E2/E3 Enzyme (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Tau Protein (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (6)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144117

GFB-12811	CDK	Metabolic Disease
GFB-12811 is a high selective *CDK5* inhibitor with an IC₅₀ of 2.3 nM .

HY-108348

BML-259	CDK	Neurological Disease
BML-259 is a potent cyclin-dependent kinase 5 *(Cdk5)* inhibitor, with IC₅₀s of 64 and 98 nM for Cdk5 and Cdk2, respectively .

HY-150082

CP681301	CDK DNA/RNA Synthesis	Cancer
CP681301 is a potent *CDK5* inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila .

HY-162683

(S)-PHA533533	CDK E1/E2/E3 Enzyme	Neurological Disease
(S)-PHA533533 is a CDK2 and *CDK5* inhibitor with blood-brain barrier permeability, with IC₅₀ values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome .

HY-123772

CDK5 inhibitor 20-223 1 Publications Verification CP668863	CDK	Cancer
CDK5 inhibitor 20-223 is a potent CDK2 and *CDK5* inhibitor with IC₅₀s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent .

HY-145694

CDK5-IN-3	CDK	Others
CDK5-IN-3 (compound 11) is a potent *CDK5* inhibitor, with IC₅₀s of 0.6 nM and 18 nM for *CDK5/p25* and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) .

HY-112468

PNU112455A hydrochloride	CDK	Cancer
PNU112455A hydrochloride is an ATP-competitive CDK2 and *CDK5* inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with K_ms of 3.6 and 3.2 μM, respectively .

HY-145693

CDK5-IN-2	CDK	Others
CDK5-IN-2 (compound 15) is a highly selective *CDK5* inhibitor with IC₅₀s of 0.2 and 23 for CDK5/p25 and CDK2/CycA, respectively .

HY-139725

CDK5-IN-1 1 Publications Verification	CDK	Metabolic Disease
CDK5-IN-1 is a potent *CDK5* inhibitor with an IC₅₀ less than 10 nM. CDK5-IN-1 is greater than 100-fold more active against CDK5 than CDK2. CDK5-IN-1 is used for kidney diseases research .

HY-173347

BLINK11	CDK	Neurological Disease
BLINK11 is a BBB-penetrant *CDK5* inhibitor. BLINK11 lowers CDK5 activity for both complexes *CDK5/p35* (IC₅₀ = 17.09 nM) and *CDK5/p25* (IC₅₀ = 14.69 nM). BLINK11 offers anti-diabetic and neuroprotective benefits. BLINK11 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice .

HY-147387

DSS30	CDK Amyloid-β	Inflammation/Immunology
DSS30 is a *P25/CDK5* inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease .

HY-173348

BLINK15	CDK	Neurological Disease
BLINK15 is a BBB-penetrant *CDK5* inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC₅₀ = 29.34 nM) and CDK5/p25 (IC₅₀ = 12.08 nM). BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice .

HY-112382

Iso-Olomoucine	Drug Isomer	Others
Iso-olomoucine is an inactive stereoisomer of the *CDK5* inhibitor olomoucine with IC₅₀ >1 mM .

HY-N3593

Clausine Z 1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde	CDK	Others
Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia .

HY-108348R

BML-259 (Standard)	Reference Standards CDK	Neurological Disease
BML-259 (Standard) is the analytical standard of BML-259 (HY-108348). This product is intended for research and analytical applications. BML-259 is a potent cyclin-dependent K_inase 5 (Cdk5) inhibitor, with IC₅₀s of 64 and 98 nM for Cdk5 and Cdk2, respectively .

HY-183280

17β-HSD10/CDK5-IN-1	17β-HSD CDK Amyloid-β Tau Protein Reactive Oxygen Species (ROS)	Neurological Disease
17β-HSD10/CDK5-IN-1 is a poent dual 17β-HSD10 and *CDK5* inhibitor with IC₅₀s of 2.44 and 0.26 μM for 17β-HSD10 and CDK5, respectively. 17β-HSD10/CDK5-IN-1 reduces ROS accumulation, attenuates pathological Tau phosphorylation, reduces Aβ plaque deposition, and ameliorates cognitive deficits in Alzheimer's mice. 17β-HSD10/CDK5-IN-1 can be used for the research of Alzheimer's disease .

Clausine Z 1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde	Alkaloids Rutaceae Plants Clausena excavata N. L. Burman Indole Alkaloids Source Classification	CDK
Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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cdk5+inhibitor

Inhibitors & Agonists

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Natural
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