CDK5-IN-3
Based on 1 Customer Validation
CDK5-IN-3 (compound 11) is a potent CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
For research use only. We do not sell to patients.
- Purity: 99.49%
- CAS No.: 2639542-32-6
- Formula: C22H26N4O
- Molecular Weight:362.47
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
|
Cdk5/p25 0.6 nM (IC50) |
CDK2/CycA 18 nM (IC50) |
Chemical Information
-
CAS No. 2639542-32-6
-
Appearance Solid
-
Molecular Weight 362.47
-
Formula C22H26N4O
-
Color Light yellow to yellow
-
SMILES
C[C@@](C1=CC=C2C(C=C(NC3=CC=CC=C3)N=C2)=N1)(O)C4CCN(C)CC4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (27.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7588 mL | 13.7942 mL | 27.5885 mL | 68.9712 mL |
| 5 mM | 0.5518 mL | 2.7588 mL | 5.5177 mL | 13.7942 mL | |
| 10 mM | 0.2759 mL | 1.3794 mL | 2.7588 mL | 6.8971 mL | |
| 15 mM | 0.1839 mL | 0.9196 mL | 1.8392 mL | 4.5981 mL | |
| 20 mM | 0.1379 mL | 0.6897 mL | 1.3794 mL | 3.4486 mL | |
| 25 mM | 0.1104 mL | 0.5518 mL | 1.1035 mL | 2.7588 mL |