2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK5-IN-3

CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).

For research use only. We do not sell to patients.

CDK5-IN-3 Chemical Structure

CDK5-IN-3 Chemical Structure

CAS No. : 2639542-32-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 550 In-stock
50 mg USD 950 In-stock
100 mg USD 1550 In-stock
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Based on 1 publication(s) in Google Scholar

CDK5-IN-3 Related Antibodies

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Description

CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

IC50 & Target[1]

Cdk5/p25

0.6 nM (IC50)

CDK2/CycA

18 nM (IC50)

Molecular Weight

362.47

Formula

C22H26N4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@@](C1=CC=C2C(C=C(NC3=CC=CC=C3)N=C2)=N1)(O)C4CCN(C)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (27.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7588 mL 13.7942 mL 27.5885 mL
5 mM 0.5518 mL 2.7588 mL 5.5177 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7588 mL 13.7942 mL 27.5885 mL 68.9712 mL
5 mM 0.5518 mL 2.7588 mL 5.5177 mL 13.7942 mL
10 mM 0.2759 mL 1.3794 mL 2.7588 mL 6.8971 mL
15 mM 0.1839 mL 0.9196 mL 1.8392 mL 4.5981 mL
20 mM 0.1379 mL 0.6897 mL 1.3794 mL 3.4486 mL
25 mM 0.1104 mL 0.5518 mL 1.1035 mL 2.7588 mL
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CDK5-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK5-IN-32639542-32-6CDKCyclin dependent kinaseautosomaldominantpolycystickidneyADPKDInhibitorinhibitorinhibit

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