1. Cell Cycle/DNA Damage
  2. CDK
  3. CP681301

CP681301 

Cat. No.: HY-150082
Handling Instructions

CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila.

For research use only. We do not sell to patients.

CP681301 Chemical Structure

CP681301 Chemical Structure

CAS No. : 865317-32-4

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Description

CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila[1].

In Vitro

CP681301 (1 µM; 96 h) shows variably cytotoxic to the tested GSC cultures but is not toxic to NHNPs[1].
CP681301 (0, 10, 50 µM; 48 h) decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs[1].
CP681301 (0, 0.5, 1 µM; ) suppresses the expression of CREB Ser133 phosphorylation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: NHNP, N12.159, GBM121, GBM39, N08-74 cells
Concentration: 1 µM
Incubation Time: 96 h
Result: Showed variably cytotoxic to the tested GSC cultures but was not toxic to NHNPs (normal human neuro-progenitors).

Western Blot Analysis[1]

Cell Line: GBM 121, GBM39 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Suppressed the expression of CD133, OLIG2, and SOX2 and cell proliferation marker KI67.
In Vivo

CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 0- to 2-day-old adult Drosophila (brat-RNAi tumors)[1]
Dosage: 1 mM
Administration: Fed, 10 days
Result: Reduced active phospho-dCdk5 (Y15) in tumor cells and the self-renewal properties of stem cells, increased the expression of neuronal marker ElaV in these cells and increased the median survival by 2.8-fold.
Molecular Weight

298.38

Formula

C17H22N4O

CAS No.
SMILES

O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(N(C)C)C=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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