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Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease .
Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml . Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml .
AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease .
DL-Leucyl-DL-phenylalanine is a dipeptide and can be used as a substrate to detecte two regions of dipeptidase staining on a gel in Drosophila simulans as well as in Drosophila melanogaster .
Drosocin is a biological active peptide. (Drosocin is a 19-mer cationic antimicrobial peptide from Drosophila melanogaster. In Drosophila native drosocin carries a disaccharide moiety attached to a threonine residue in mid-chain position. This synthetic drosocin peptide of identical amino acid sequence without the disaccharide has an activity several times lower than the native compound.)
(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila .
Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor .
Endothion, a systemic insecticide, has been used for agricultural and horticultural areas. Endothion can prevent Mediterranean Drosophila on peaches, and the residual effect lasts for more than 3 weeks without toxicity to leaves and fruits .
O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability. O4I4 extends lifespan in Caenorhabditis elegans and Drosophila. O4I4 can be used for regenerative medicine and rejuvenation research .
Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models .
Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).
AUTEN-67 (inner salt), the inner salt form of AUTEN-67 (HY-117924), is an orally active autophagy-enhancing agent and MTMR14 inhibitor with potent antiaging and neuroprotective effects. AUTEN-67 (inner salt) hampers the progression of neurodegenerative symptoms in a drosophila model of Huntington's disease .
SecinH3 is an antagonist of cytohesins with IC50s of 5.4 μM, 2.4 μM, 5.4 μM, 5.6 μM, 5.6 μM and 65 μM for hCyh1, hCyh2, mCyh3, hCyh3, drosophila steppke and yGea2-S7, respectively.
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research .
YM-1 is a stable and soluble MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins .
AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease .
Antennapedia Peptide (Penetratin peptide) TFA is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of cell-penetrating peptides.
Drosocin is a biological active peptide. (Drosocin is a 19-mer cationic antimicrobial peptide from Drosophila melanogaster. In Drosophila native drosocin carries a disaccharide moiety attached to a threonine residue in mid-chain position. This synthetic drosocin peptide of identical amino acid sequence without the disaccharide has an activity several times lower than the native compound.)
Antennapedia Peptide (Penetratin peptide) is a 16 amino acid peptide, originally derived from the 60 amino acid long homeodomain of the Drosophila transcription factor Antennapedia and is a member of the family of cell-penetrating peptides.
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research .
Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 μg/ml . Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 μg/ml), inhibits the immunoresponse in human innate immunity through TNF-α signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 μg/ml .
(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila .
Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models .
Bone morphogenetic protein 1 (BMP-1), also known as metalloproteinases, belongs to the BMP-1/tolloidlike proteinases (BTP) family. BMP-1 is also a signature extracellular matrix (ECM) protein associated with high metastatic potential in breast tumors. BMP-1 processes growth factors, including TGF-β, BMP-2, BMP-4, and GFD8, regulates morphogenesis, and mediates the cleavage of COOH-terminal propeptide of type I procollagen (CICP) in the extracellular space. The total length of human BMP-1 protein is 986 amino acids (M1-K986), with 4 glycosylation domains. BMP-1 Protein, Human (His) has a total length of 866 amino acids (A121-K986), is expressed in E. coli cells with a N-terminal *His-tag.
Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is 466 a.a., with molecular weight of 53 kDa.
DLL1 protein is a transmembrane ligand for NOTCH1, NOTCH2 and NOTCH3 receptors and participates in cis- and trans-interactions. Trans interactions trigger mechanical forces involving clathrin-mediated endocytosis, ligand ubiquitination, EPN1 interactions, and actin polymerization. Delta-like protein 1/DLL1 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Delta-like protein 1/DLL1 Protein, Human (HEK293, His) is 523 a.a., with molecular weight of ~65.0 kDa.
Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (498a.a, HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (498a.a, HEK293, His) is 498 a.a., with molecular weight of 55-70 kDa.
SMAD2 protein, an R-SMAD, acts as a transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. It binds TRE elements, regulating TGF-beta target genes. Forming a complex with SMAD4, it promotes transcription, positively regulating PDPK1 and showing potential tumor suppressor functions in colorectal carcinoma. SMAD2 interacts with various proteins, participating in signal transduction and transcriptional regulation. SMAD2 Protein, Human (His-SUMO) is the recombinant human-derived SMAD2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of SMAD2 Protein, Human (His-SUMO) is 466 a.a., with molecular weight of ~68.2 kDa.
ADH Protein, Drosophila melanogaster (S2-I256) is a dimeric Zn-containing enzyme in the oxidoreductase family with acetaldehyde dehydrogenase and alcohol dehydrogenase activity, therefore, can oxidize primary and secondary alcohols. ADH Protein, Drosophila melanogaster (S2-I256) is E.coli-sourced and tag-free, the initiator methionine is naturally removed. ADH Protein, Drosophila melanogaster is the recombinant ADH protein, expressed by E. coli , with tag free. The total length of ADH Protein, Drosophila melanogaster is 255 a.a., .
ADH Protein, Drosophila melanogaster (S2-I256) is a dimeric Zn-containing enzyme in the oxidoreductase family with acetaldehyde dehydrogenase and alcohol dehydrogenase activity, therefore, can oxidize primary and secondary alcohols. ADH Protein, Drosophila melanogaster (S2-I256) is E.coli-sourced and tag-free, the initiator methionine is naturally removed. ADH Protein, Drosophila melanogaster (His, Strep) is the recombinant ADH protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of ADH Protein, Drosophila melanogaster (His, Strep) is 255 a.a., .
Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (P.pastoris, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Human (P.pastoris, His) is 466 a.a., with molecular weight of ~56 kDa.
Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch3 Protein, Human (HEK293, Fc) is the recombinant human-derived Notch3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Notch3 Protein, Human (HEK293, Fc) is 428 a.a., with molecular weight of 75-83 kDa.
Frizzled-6 is a Wnt receptor that complexly activates signaling pathways that converge primarily on the β-catenin canonical pathway. This triggers disorganized protein activation, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. Frizzled-6 Protein, Human (HEK293, His) is the recombinant human-derived Frizzled-6 protein, expressed by HEK293 , with C-His labeled tag. The total length of Frizzled-6 Protein, Human (HEK293, His) is 135 a.a., with molecular weight of ~20-28 kDa.
Frizzled-6 is a Wnt receptor that complexly activates signaling pathways that converge primarily on the β-catenin canonical pathway. This triggers disorganized protein activation, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. Frizzled-6 Protein, Human (HEK293, Fc) is the recombinant human-derived Frizzled-6 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Frizzled-6 Protein, Human (HEK293, Fc) is 135 a.a., with molecular weight of ~42 kDa.
The DCTN1 protein is a central player in intracellular trafficking within the dynein complex, guiding dynein-driven retrograde movement along microtubules. It recruits dynein to microtubules, enhancing vesicle and organelle transport. DCTN1 Protein, Human (His-SUMO) is the recombinant human-derived DCTN1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of DCTN1 Protein, Human (His-SUMO) is 335 a.a., with molecular weight of ~55.2 kDa.
FZD2 is a Wnt receptor that primarily activates the β-catenin classical pathway, involving disheveled protein, GSK-3 kinase inhibition, nuclear β-catenin accumulation, and Wnt target gene activation. Although some family members exhibit second PKC and calcium flux pathways, the precise differentiation and integration with the canonical pathways remains unclear. FZD2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FZD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FZD2 Protein, Mouse (HEK293, Fc) is 140 a.a., with molecular weight of 55-60 kDa.
The Frizzled-10/CD350 gene is a member of the Frizzled gene family, encoding a 7-transmembrane domain protein that acts as a receptor for the Wingless-type MMTV integration site family signaling protein. Most Frizzled receptors, including Frizzled-10/CD350, are involved in cell signaling, specifically the β-catenin classical pathway. Frizzled-10/CD350 Protein, Human (HEK293, His) is the recombinant human-derived Frizzled-10/CD350 protein, expressed by HEK293 , with C-His labeled tag. The total length of Frizzled-10/CD350 Protein, Human (HEK293, His) is 141 a.a., with molecular weight of 20-25 kDa.
Frizzled-10/CD350 belongs to the G-protein coupled receptor Fz/Smo family. Frizzled-10/CD350 Protein, Human (HEK293, Fc) is the recombinant human-derived Frizzled-10/CD350 protein, expressed by HEK293, with C-hFc labeled tag. The total length of Frizzled-10/CD350 Protein, Human (HEK293, Fc) is 161 a.a., with molecular weight of ~48.7 kDa.
Frizzled-5 protein is a receptor for Wnt proteins (WNT2, WNT10B, WNT5A), which can activate WNT7A and promote the formation of synapses in neurons. It participates in the canonical Wnt/β-catenin pathway, activating disheveled proteins, inhibiting GSK-3 kinase, and triggering Wnt target genes. Frizzled-5 Protein, Human (HEK293, His) is the recombinant human-derived Frizzled-5 protein, expressed by HEK293 , with C-His labeled tag. The total length of Frizzled-5 Protein, Human (HEK293, His) is 141 a.a., with molecular weight of 25-30 kDa.
Frizzled-5 protein is a receptor for Wnt proteins (WNT2, WNT10B, WNT5A), which can activate WNT7A and promote the formation of synapses in neurons. It participates in the canonical Wnt/β-catenin pathway, activating disheveled proteins, inhibiting GSK-3 kinase, and triggering Wnt target genes. Frizzled-5 Protein, Human (HEK293, Fc) is the recombinant human-derived Frizzled-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Frizzled-5 Protein, Human (HEK293, Fc) is 141 a.a., with molecular weight of ~42.7 kDa.
Frizzled-4/CD344 is a Wnt receptor that mainly activates the β-catenin pathway and affects retinal vascularization. As a receptor for Wnt proteins and Norrin protein (NDP), it stimulates LEF/TCF-mediated transcriptional programs. Frizzled-4/CD344 Protein, Rat (HEK293, His) is the recombinant rat-derived Frizzled-4/CD344 protein, expressed by HEK293 , with C-His labeled tag. The total length of Frizzled-4/CD344 Protein, Rat (HEK293, His) is 144 a.a., with molecular weight of ~23-30 kDa.
Frizzled-4/CD344 is a Wnt receptor that mainly activates the β-catenin pathway and affects retinal vascularization. As a receptor for Wnt proteins and Norrin protein (NDP), it stimulates LEF/TCF-mediated transcriptional programs. Frizzled-4/CD344 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Frizzled-4/CD344 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Frizzled-4/CD344 Protein, Rat (HEK293, Fc) is 181 a.a., with molecular weight of ~113 & 58 & 36 kDa, respectively.
ELAV embryonic lethal abnormal vision drosophila; like 4; ELAV L4; ELAV like 4; ELAV like protein 4; ELAV-like protein 4; ELAV4_HUMAN; Elavl4; Embryonic lethal abnormal vision drosophila homolog of like 4; Hu antigen D; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD; PNEM
ELAVL4 protein is a broad RNA-binding factor that post-transcriptionally regulates mRNAs such as GAP43, VEGF, FOS, CDKN1A, and ACHE, stabilizing and protecting them from decay by binding to ARE sequences. It reduces mRNA deadenylation and enhances mRNA binding affinity by interacting with the Poly(A) tail. ELAVL4 Protein, Human (His-SUMO) is the recombinant human-derived ELAVL4 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag. The total length of ELAVL4 Protein, Human (His-SUMO) is 380 a.a., with molecular weight of ~61.8 kDa.
Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. FITC-Labeled Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled Delta-like protein 3/DLL3 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-Labeled Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is 466 a.a., with molecular weight of 50-55 kDa.
CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (His) is the recombinant human-derived CSNK1E protein, expressed by E. coli , with N-6*His labeled tag. The total length of CSNK1E Protein, Human (His) is 416 a.a., with molecular weight of ~51.3 kDa.
CSNK1E, a member of the casein kinase family, is characterized by its preferential phosphorylation of acidic proteins, particularly caseins. The protein plays a pivotal role in Wnt signaling, as evidenced by its phosphorylation of DVL1 and DVL2, contributing to the intricate regulation of this pathway. Beyond its involvement in Wnt signaling, CSNK1E serves as a central component of the circadian clock, influencing the circadian period length by orchestrating the speed and rhythmicity of PER1 and PER2 phosphorylation. Acting in equilibrium with PP1, it governs the nuclear transport and degradation of PER1 and PER2, thereby intricately regulating the circadian rhythm. Additionally, CSNK1E demonstrates its regulatory influence by inhibiting cytokine-induced granulocytic differentiation, further emphasizing its multifaceted roles in cellular processes. CSNK1E Protein, Human (P. pastoris, His) is the recombinant human-derived CSNK1E protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CSNK1E Protein, Human (P. pastoris, His) is 416 a.a., with molecular weight of 49.3 kDa.
Shh Antibody is an unconjugated, approximately 19/47 kDa, rabbit-derived, anti-Shh polyclonal antibody. Shh Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, cow, horse, rabbit background without labeling.
Fascin Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 55 kDa, targeting to Fascin. It can be used for WB,IHC-F,IHC-P,ICC/IF,FC,IP assays with tag free, in the background of Human, Mouse, Rat, Monkey.
ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; Class A basic helix-loop-helix protein 38; CRS1; H-twist; OTTHUMP00000116043; SCS; Twist basic helix loop helix transcription factor 1; Twist homolog 1 (drosophila); Twist homolog 1; TWIST homolog of drosophila; Twist related protein 1; Twist-related protein 1; Twist1; TWST1_HUMAN.
WB; ELISA; IHC-P; IHC-F; IF
Human, Mouse, Rat,
TWIST Antibody is an unconjugated, approximately 23 kDa, rabbit-derived, anti-TWIST polyclonal antibody. TWIST Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, background without labeling.
MAD (mothers against decapentaplegic drosophila) homolog 7; MAD; Mad homolog 7; MAD mothers against decapentaplegic homolog 7; MADH 7; MADH 8; MADH8; Mothers Against Decapentaplegic drosophila Homolog of 7; Mothers against decapentaplegic homolog 7; Mothers against decapentaplegic homolog 8; Mothers against DPP homolog 7; Mothers against DPP homolog 8; SMA- AND MAD-RELATED PROTEIN 7; SMAD 7; SMAD; SMAD family member 7; SMAD, mothers against DPP homolog 7 (drosophila); SMAD, mothers against DPP homolog 7; SMAD7_HUMAN.
WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF
Human, Mouse, Rat(predicted: Pig, Cow)
SMAD7 Antibody is an unconjugated, approximately 46 kDa, rabbit-derived, anti-SMAD7 polyclonal antibody. SMAD7 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: pig, cow background without labeling.
LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large tumor supressor, homolog 1; LATS, large tumor suppressor, homolog 1 (drosophila); LATS, large tumor suppressor, homolog 2 (drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.
WB; ELISA; IHC-P; IHC-F; IF
Human, Mouse(predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit)
phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody is an unconjugated, approximately 124 kDa, rabbit-derived, anti-phospho-LATS1+LATS2 (Thr1079 +Thr1041) polyclonal antibody. phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, chicken, dog, pig, cow, horse, rabbit background without labeling.
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