1. Anti-infection
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Parasite
    GABA Receptor
  3. Lotilaner

Lotilaner 

Cat. No.: HY-116564
Handling Instructions

Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor.

For research use only. We do not sell to patients.

Lotilaner Chemical Structure

Lotilaner Chemical Structure

CAS No. : 1369852-71-0

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Description

Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1].

IC50 & Target

IC50: 23.84 nM (DmS-GABA), 38.25 nM (DmR2-GABA), 52.40 nM (Ls-GABA1), 36.79 nM (Rm-GABA)[1]

In Vitro

Lotilaner shows IC50s of 38.25 ± 3.75, 52.40 ± 4.54, 36.79 ± 4.39 nM for Drosophila melanogaster dieldrin/fipronil-resistant forms (DmR2), Lepeophtheirus salmonis (Ls) and Rhipicephalus microplus (Rm) GABACl receptors, respectively[1].

Molecular Weight

596.76

Formula

C₂₀H₁₄Cl₃F₆N₃O₃S

CAS No.

1369852-71-0

SMILES

O=C(NCC(NCC(F)(F)F)=O)C1=C(C=C(S1)C2=NO[[email protected]](C3=CC(Cl)=C(C(Cl)=C3)Cl)(C2)C(F)(F)F)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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