2. Protein Tyrosine Kinase/RTK
    MAPK/ERK Pathway
  3. RET
    Raf
    Ribosomal S6 Kinase (RSK)
    Src
  4. AD57

AD57 

Cat. No.: HY-18507 Purity: 98.08%
COA Handling Instructions

AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity.

For research use only. We do not sell to patients.

AD57 Chemical Structure

AD57 Chemical Structure

CAS No. : 1093380-42-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 275 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 900 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AD57 is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src, with greatly reduces mTOR activity[1].

IC50 & Target[1]

Braf

 

In Vitro

AD57 (0.2 nM) significantly inhibits the ptc > dRetMEN2B lethality in the larva of Drosophila[1].
AD57 (0.1 nM) enhances survival of ptc > dRetMEN2B by reducing erk gene dosage in Drosophila[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

AD57 inhibits the viability of MEN2B (MZ-CRC-1) and MEN2A (TT) patient-derived cell lines in RETMEN2 models[1].
AD57 (20 mg/kg) significantly inhibits TT-based tumour growth without obvious cytotoxicity in conventional mouse xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

455.44

Appearance

Solid

Formula

C22H20F3N7O
CAS No.
SMILES

O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C3=NN(C(C)C)C4=C3C(N)=NC=N4)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (274.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1957 mL 10.9784 mL 21.9568 mL
5 mM 0.4391 mL 2.1957 mL 4.3914 mL
10 mM 0.2196 mL 1.0978 mL 2.1957 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AD571093380-42-7AD 57AD-57RETRafRibosomal S6 Kinase (RSK)SrcRaf kinasesS6Kptc?>?dRetMEN2BDrosophilaMouseMEN2BMEN2AInhibitorinhibitorinhibit

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