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Cat. No.: HY-18507A

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AD57 hydrochloride

AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src.

For research use only. We do not sell to patients.

CAS No.: 2320261-72-9
Formula: C₂₂H₂₁ClF₃N₇O
Molecular Weight:491.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

AD57 hydrochloride Chemical Structure

CAS No.: 2320261-72-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src^[1].

All Raf Isoforms :

All Ribosomal S6 Kinase (RSK) Isoforms :

All Src Isoforms :

Chemical Information

CAS No. 2320261-72-9
Molecular Weight 491.90
Formula C₂₂H₂₁ClF₃N₇O
SMILES

O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C3=NN(C(C)C)C4=C3C(N)=NC=N4)C=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 6;486(7401):80-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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AD57 hydrochloride

All Raf Isoforms

All Ribosomal S6 Kinase (RSK) Isoforms

All Src Isoforms