O4I4
Based on 1 Customer Validation
O4I4 (compound 23) is a OCT4-inducing compound with metabolical stability. O4I4 extends lifespan in Caenorhabditis elegans and Drosophila. O4I4 can be used for regenerative medicine and rejuvenation research.
For research use only. We do not sell to patients.
- Purity: 98.73%
- CAS No.: 412008-21-0
- Formula: C15H20N2S
- Molecular Weight:260.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
0.26 μM
Compound: 19
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Displacement of [125I]TARC from CCR4 expressed in human CEM cell line
Displacement of [125I]TARC from CCR4 expressed in human CEM cell line
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[PMID: 16497499] |
| HFF | IC50 |
>20 μM
Compound: 23; O4, O4I4
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Cytotoxicity against human HFF cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HFF cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
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[PMID: 37253308] |
| NCCIT | IC50 |
10.94 μM
Compound: 23; O4, O4I4
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Cytotoxicity against human NCCIT cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human NCCIT cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay
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[PMID: 37253308] |
Chemical Information
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CAS No. 412008-21-0
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Appearance Solid
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Molecular Weight 260.40
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Formula C15H20N2S
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Color White to off-white
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SMILES
CC1=C(C(NC2=NC(C(C)(C)C)=CS2)=CC=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (960.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8402 mL | 19.2012 mL | 38.4025 mL | 96.0061 mL |
| 5 mM | 0.7680 mL | 3.8402 mL | 7.6805 mL | 19.2012 mL | |
| 10 mM | 0.3840 mL | 1.9201 mL | 3.8402 mL | 9.6006 mL | |
| 15 mM | 0.2560 mL | 1.2801 mL | 2.5602 mL | 6.4004 mL | |
| 20 mM | 0.1920 mL | 0.9601 mL | 1.9201 mL | 4.8003 mL | |
| 25 mM | 0.1536 mL | 0.7680 mL | 1.5361 mL | 3.8402 mL | |
| 30 mM | 0.1280 mL | 0.6400 mL | 1.2801 mL | 3.2002 mL | |
| 40 mM | 0.0960 mL | 0.4800 mL | 0.9601 mL | 2.4002 mL | |
| 50 mM | 0.0768 mL | 0.3840 mL | 0.7680 mL | 1.9201 mL | |
| 60 mM | 0.0640 mL | 0.3200 mL | 0.6400 mL | 1.6001 mL | |
| 80 mM | 0.0480 mL | 0.2400 mL | 0.4800 mL | 1.2001 mL | |
| 100 mM | 0.0384 mL | 0.1920 mL | 0.3840 mL | 0.9601 mL |
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