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Cat. No.: HY-122989

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Aristolactam BIII

Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC₅₀= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models.

For research use only. We do not sell to patients.

CAS No.: 53948-10-0
Formula: C₁₈H₁₅NO₄
Molecular Weight:309.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Aristolactam BIII Chemical Structure

CAS No.: 53948-10-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All DYRK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
B-cell	IC₅₀	1.98 μM Compound: 24	Inhibition of LPS-induced BALB/c mouse B cell proliferation Inhibition of LPS-induced BALB/c mouse B cell proliferation	[PMID: 17081761]
HCT-15	GI₅₀	3.35 μM Compound: 6	Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay Antiproliferative activity against multidrug resistant human HCT15/CLO2 cells by SRB assay	[PMID: 19394218]
HCT-15	GI₅₀	3.74 μM Compound: 6	Antiproliferative activity against human HCT15 cells by SRB assay Antiproliferative activity against human HCT15 cells by SRB assay	[PMID: 19394218]
MES-SA	GI₅₀	2.7 μM Compound: 6	Antiproliferative activity against human MESSA cells by SRB assay Antiproliferative activity against human MESSA cells by SRB assay	[PMID: 19394218]
MES-SA/Dx5	GI₅₀	2.82 μM Compound: 6	Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay Antiproliferative activity against multidrug resistant human MES-SA/Dx5 cells by SRB assay	[PMID: 19394218]
T-cell	IC₅₀	2.29 μM Compound: 24	Inhibition of ConA-induced BALB/c mouse T cell proliferation Inhibition of ConA-induced BALB/c mouse T cell proliferation	[PMID: 17081761]

Chemical Information

CAS No. 53948-10-0
Molecular Weight 309.32
Formula C₁₈H₁₅NO₄
SMILES

O=C1NC2=C3C1=CC(OC)=C(OC)C3=C4C(C=CC(OC)=C4)=C2
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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