53948-10-0
53948-10-0
Chemical Structure
Aristolactam BIII
- CAS No.: 53948-10-0
- Formula:C18H15NO4
- Molecular Weight:309.32
IUPAC Name: 1,2,9-trimethoxydibenzo[cd,f]indol-4(5H)-one
InChIKey: OQKGOEOSXXHWFQ-UHFFFAOYSA-N
SMILES: O=C1NC2=C3C1=CC(OC)=C(OC)C3=C4C(C=CC(OC)=C4)=C2
Biological Activity: Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Aristolactam BIII | Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
