2. Cell Cycle/DNA Damage
  3. CDK
  4. BML-259

BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively.

For research use only. We do not sell to patients.

BML-259 Chemical Structure

BML-259 Chemical Structure

CAS No. : 267654-00-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 96 In-stock
25 mg USD 210 In-stock
50 mg USD 365 In-stock
100 mg USD 620 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

BML-259 Related Antibodies

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Description

BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].

In Vitro

BML-259 (10 μM) protects large population of cells against non-Aβ component of Alzheimer's disease amyloid (NAC)-evoked cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BML-259 Related Antibodies
Molecular Weight

260.35

Formula

C14H16N2OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC=C(C(C)C)S1)CC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (480.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8410 mL 19.2049 mL 38.4098 mL
5 mM 0.7682 mL 3.8410 mL 7.6820 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8410 mL 19.2049 mL 38.4098 mL 96.0246 mL
5 mM 0.7682 mL 3.8410 mL 7.6820 mL 19.2049 mL
10 mM 0.3841 mL 1.9205 mL 3.8410 mL 9.6025 mL
15 mM 0.2561 mL 1.2803 mL 2.5607 mL 6.4016 mL
20 mM 0.1920 mL 0.9602 mL 1.9205 mL 4.8012 mL
25 mM 0.1536 mL 0.7682 mL 1.5364 mL 3.8410 mL
30 mM 0.1280 mL 0.6402 mL 1.2803 mL 3.2008 mL
40 mM 0.0960 mL 0.4801 mL 0.9602 mL 2.4006 mL
50 mM 0.0768 mL 0.3841 mL 0.7682 mL 1.9205 mL
60 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6004 mL
80 mM 0.0480 mL 0.2401 mL 0.4801 mL 1.2003 mL
100 mM 0.0384 mL 0.1920 mL 0.3841 mL 0.9602 mL
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BML-259 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BML-259267654-00-2BML259BML 259CDKCyclin dependent kinaseAlzheimer'sdisease,neurotoxicityp53proteincelldeathInhibitorinhibitorinhibit

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