1. Cell Cycle/DNA Damage
  2. CDK
  3. PNU112455A hydrochloride

PNU112455A hydrochloride 

Cat. No.: HY-112468 Purity: 99.62%
Handling Instructions

PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.

For research use only. We do not sell to patients.

PNU112455A hydrochloride Chemical Structure

PNU112455A hydrochloride Chemical Structure

CAS No. : 21886-12-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 94 In-stock
Estimated Time of Arrival: December 31
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 155 In-stock
Estimated Time of Arrival: December 31
50 mg USD 545 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PNU112455A hydrochloride is an ATP-competitive CDK2 and CDK5 inhibitor. PNU112455A hydrochloride binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively[1].

IC50 & Target[1]

CDK2

3.6 μM (Km)

CDK5

3.2 μM (Km)

Molecular Weight

301.75

Formula

C₁₀H₁₂ClN₅O₂S

CAS No.

21886-12-4

SMILES

O=S(C1=CC=C(NC2=NC=NC(N)=C2)C=C1)(N)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (414.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3140 mL 16.5700 mL 33.1400 mL
5 mM 0.6628 mL 3.3140 mL 6.6280 mL
10 mM 0.3314 mL 1.6570 mL 3.3140 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

PNU112455ACDKCyclin dependent kinaseATPsiteanticooperativecompetitiveAlzheimer'sdiseaseInhibitorinhibitorinhibit

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Product Name:
PNU112455A hydrochloride
Cat. No.:
HY-112468
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