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Cat. No.: HY-N3593

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Clausine Z

(Synonyms: 1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde)

Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia.

For research use only. We do not sell to patients.

CAS No.: 866111-14-0
Formula: C₁₃H₉NO₃
Molecular Weight:227.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Clausine Z Chemical Structure

CAS No.: 866111-14-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia^[1].

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	135 μM Compound: 4	Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]

Chemical Information

CAS No. 866111-14-0
Molecular Weight 227.22
Formula C₁₃H₉NO₃
SMILES

O=CC1=CC2=C(C(O)=C1)NC3=C2C=C(O)C=C3
Synonyms

1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Potterat O, et al. Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5. Pharmazie. 2005 Aug;60(8):637-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Clausine Z

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Clausine Z Related Classifications

HY-N3593 Related Classifications