Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5

  • Pharmazie. 2005 Aug;60(8):637-9.
O Potterat  1 ,  C Puder ,  W Bolek ,  K Wagner ,  Changqiang Ke ,  Yang Ye ,  F Gillardon
Affiliations
  • 1. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. [email protected]
PMID: 16124414
Abstract

A new carbazole alkaloid, named clausine Z, has been isolated from the stems and leaves of Clausena excavata Burm. (Rutaceae). Its structure was established by spectroscopic methods. The compound exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.

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