Clausena excavata N. L. Burman

Myricetin 3'-rhamnoside is a flavonoid glycoside found in the leaves and twigs of Clausena excavata Burm. f. (Rutaceae).

Clauszoline B is a natural alkaloid.

Dentatin is a natural coumarin.

Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods.

Mukonal is a natural alkaloid.

Clauszoline K is a natural alkaloid.

1-O-Methylclausenolide is a natural triterpene.

Excavatin D is a natural coumarin.

Clausine I is a natural alkaloid.

Excavatin M is a coumarin-type compound that can be isolated from the chemical constituents of the plant Clausena excavata.

Excavatin G is a novel coumarin compound that can be isolated from Clausena excavata. While the Clausena excavata plant itself has traditional uses such as insecticidal properties and relieving stomach pain, the specific key activities and functions of Excavatin G require targeted research and verification.

Clausenidin is a selective inhibitor targeting apoptosis-related pathways, including the mitochondrial pathway and death receptor pathway, and vascular endothelial growth factor (VEGF). Clausenidin induces mitochondrial membrane depolarization by activating caspase-3, caspase-8 and caspase-9, upregulating the pro-apoptotic protein Bax and downregulating the anti-apoptotic protein Bcl-2. Clausenidin also inhibits VEGF expression and blocks angiogenesis, exerting anti-tumor activity. Clausenidin has inhibitory effects against Mycobacterium tuberculosis (MIC=200 μg/mL). Clausenidin can induce apoptosis in liver cancer cells, arrest the cell cycle in the G2/M phase, and inhibit tumor angiogenesis. Clausenidin can be used in the research of malignant tumors such as liver cancer.

Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field.

Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein Mcl-1 and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma.

Mukonine is a carbazole antitumor and anti-inflammatory compound.

Glutinol (5-Glutinen-3-ol) is a Diterpenoids product that can be isolated from the heartwoods of Podocarpus macrophyllus.

21,23-Dihydro-23-hydroxy-21-oxozapoterin is a natural product.

Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia.