1083193-15-0
1083193-15-0
Chemical Structure
Nordentatin
- CAS No.: 1083193-15-0
- Formula:C19H20O4
- Molecular Weight:312.36
InChIKey: WYMMNGQSPNWCIK-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(O)=C3C=CC(C)(C)OC3=C2C(C)(C)C=C)C=C1
Biological Activity: Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein Mcl-1 and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma[1][2].
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Nordentatin | Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein Mcl-1 and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma. | |||||||||||||||||||||
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References
- [1]. Sunthitikawinsakul A, et al. Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities. Planta Med. 2003 Feb;69(2):155-7. [Content Brief]
- [2]. Boonyarat C, et al. Nordentatin Inhibits Neuroblastoma Cell Proliferation and Migration through Regulation of GSK-3 Pathway. Curr Issues Mol Biol. 2022 Feb 24;44(3):1062-1074. [Content Brief]
