CDK5-IN-1
Based on 1 publication(s) in Google Scholar
CDK5-IN-1 is a potent CDK5 inhibitor with an IC50 less than 10 nM. CDK5-IN-1 is greater than 100-fold more active against CDK5 than CDK2. CDK5-IN-1 is used for kidney diseases research.
For research use only. We do not sell to patients.
- Purity: 98.47%
- CAS No.: 2639540-19-3
- Formula: C24H25FN6O3S
- Molecular Weight:496.56
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CDK5-IN-1
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Biological Activity
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CDK5 < 10 nM (IC50) |
Chemical Information
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CAS No. 2639540-19-3
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Appearance Solid
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Molecular Weight 496.56
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Formula C24H25FN6O3S
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Color Yellow to orange
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SMILES
O=S(C1=CC=C2C=NC(NC3=CC=C(N4N=C(CO)C=C4)C=C3F)=CC2=N1)(C5CCN(CC5)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Med
Inactivation of TACC2 epigenetically represses CDKN1A and confers sensitivity to CDK inhibitors. [Abstract]2025 Jan 5:100568. PMID: 39793578
Solvent & Solubility
DMSO : 250 mg/mL (503.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0139 mL | 10.0693 mL | 20.1386 mL | 50.3464 mL |
| 5 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL | 10.0693 mL | |
| 10 mM | 0.2014 mL | 1.0069 mL | 2.0139 mL | 5.0346 mL | |
| 15 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 20 mM | 0.1007 mL | 0.5035 mL | 1.0069 mL | 2.5173 mL | |
| 25 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0139 mL | |
| 30 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6782 mL | |
| 40 mM | 0.0503 mL | 0.2517 mL | 0.5035 mL | 1.2587 mL | |
| 50 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0069 mL | |
| 60 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8391 mL | |
| 80 mM | 0.0252 mL | 0.1259 mL | 0.2517 mL | 0.6293 mL | |
| 100 mM | 0.0201 mL | 0.1007 mL | 0.2014 mL | 0.5035 mL |
CDK5-IN-1 Related Classifications
HY-139725 Related Classifications
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