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Isoforms Recommended:	FFAR2

Results for "

gpr43

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Fluorescent Dye (1) Free Fatty Acid Receptor (13) Small Interfering RNA (siRNA) (3)
By Research Areas:	Infection (1) Inflammation/Immunology (2) Metabolic Disease (11)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Targets Recommended: GPR39 G2A (GPR132) EBI2/GPR183 GPR84 Kisspeptin Receptor Succinate Receptor 1 GPR55 GPR88 GPR171 GPR35 GPR119 GPR4 GPR139 GPR6 GPR65 GPR52 GPR68 GPR109A MCHR1 (GPR24) CX3CR1 Neuropeptide S Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12940

GLPG0974 Maximum Cited Publications 17 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC₅₀ of 9 nM.

HY-P1125

4-CMTB 5+ Cited Publications	Free Fatty Acid Receptor	Others
4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC₅₀=6.38) .

HY-112813

TUG-1375 4 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pK_i of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ .

HY-116263

CATPB 2 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
CATPB is a potent, selective free fatty acid receptor 2 (FFA2R/GPR43) antagonist .

HY-114011

AMG7703	Free Fatty Acid Receptor	Metabolic Disease Inflammation/Immunology
AMG7703 is a selective and allosteric agonists of FFA2 (GPR43), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic .

HY-12940A

(S)-GLPG0974	Free Fatty Acid Receptor	Metabolic Disease
(S)-GLPG0974 is the isomer of GLPG0974 (HY-12940), and can be used as an experimental control. GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC₅₀ of 9 nM.

HY-119242

BTI-A-404	Free Fatty Acid Receptor	Metabolic Disease Inflammation/Immunology
BTI-A-404 is a potent, selective and competitive inverse agonist of human GPR43. BTI-A-404 can be used for the research of inflammation, obesity and type 2 diabetes .

HY-RS04875

FFAR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FFAR2 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FFAR2 Human Pre-designed siRNA Set A FFAR2 Human Pre-designed siRNA Set A

HY-W727728

MK-8666	Free Fatty Acid Receptor	Metabolic Disease
MK-8666 is a potent and selective partial *GPR40* agonist (EC₅₀ = 0.54 nM for human GPR40). MK-8666 shows selectivity over GPR119, GPR43, GPR41, GPR120, and other G-protein-coupled receptors (GPCRs). MK-8666 reduces glucose in the rodent. MK-8666 can be used for type 2 diabetes research ^[1][2].

HY-111141

AM-3189	Free Fatty Acid Receptor	Metabolic Disease
AM-3189 is an orally active and selective *GPR40* agonist with EC₅₀ values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes .

HY-13967

AMG 837 3 Publications Verification	Free Fatty Acid Receptor Bacterial	Infection Metabolic Disease
AMG 837 is an orally active, selective *GPR40/FFA1* agonist with an EC₅₀ of 1.5 nM against human *GPR40. AMG 837 stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models . AMG 837 binds to the BacA* protein and impairs the survival and replication of Brucella. AMG 837 can be used in research related to type 2 diabetes and brucellosis .

HY-171069

FFA2 agonist-1	Free Fatty Acid Receptor	Metabolic Disease
FFA2 agonist-1 (Compound 4) is the agonist for Free fatty acid receptor 2 (FFA2/GPR43) with an EC₅₀ of 81 nM. FFA2 agonist-1 exhibits activity in β-arrestin-2 recruitment assay and cAMP inhibition assay with EC₅₀ of 1.2 μM and 0.53 μM. FFA2 agonist-1 leads to appetite regulating peptide YY (PYY) mucosal responses, inhibits the fat accumulation, intestinal functions and food intake, and can be used for obesity research .

HY-185287

TUG-1609	Free Fatty Acid Receptor Fluorescent Dye	Others
TUG-1609 is a fluorescent tracer targeting free fatty acid receptor 2 (FFA2/GPR43) with a K_d value of 65.1 nM .

HY-182729

FFA2 agonist-2	Free Fatty Acid Receptor	Metabolic Disease
FFA2 agonist-2 is a potent agonist of the *FFA2 (GPR43) receptor, with a pEC₅₀* of 7.9 for human FFA2, and a pEC₅₀ of 7.3 for murine FFA2. FFA2 agonist-2 acts as an orthosteric agonist and shows no obvious cross‑activity against FFA1, FFA3 and FFA4. FFA2 agonist-2 can be used for FFA2 receptor research in type 2 diabetes and metabolic disorders .

HY-RS23918

Ffar2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ffar2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ffar2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar2 Rat Pre-designed siRNA Set A Ffar2 Rat Pre-designed siRNA Set A

HY-RS16257

Ffar2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ffar2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ffar2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar2 Mouse Pre-designed siRNA Set A Ffar2 Mouse Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81225

	GPR43 Antibody GPCR gpr43; FFA2R; Ffar2; FFAR2_HUMAN; free fatty acid activated receptor 2; Free fatty acid receptor 2; G protein coupled receptor 43; G protein-coupled receptor 43; G-protein coupled receptor 43; gpr 43; GPCR 43.	IHC-P, IHC-F, ICC/IF, ELISA, IF-Tissue	Human, Mouse
	GPR43 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GPR43.

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FFAR2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FFAR2 Human Pre-designed siRNA Set A contains three designed siRNAs for FFAR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ffar2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ffar2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ffar2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ffar2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ffar2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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