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Cat. No.: HY-182729

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FFA2 agonist-2

FFA2 agonist-2 is a potent agonist of the FFA2 (GPR43) receptor, with a pEC₅₀ of 7.9 for human FFA2, and a pEC₅₀ of 7.3 for murine FFA2. FFA2 agonist-2 acts as an orthosteric agonist and shows no obvious cross‑activity against FFA1, FFA3 and FFA4. FFA2 agonist-2 can be used for FFA2 receptor research in type 2 diabetes and metabolic disorders.

For research use only. We do not sell to patients.

CAS No.: 1229363-11-4
Formula: C₂₃H₂₀Cl₂N₂O₃S
Molecular Weight:475.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FFA2 agonist-2 Chemical Structure

CAS No.: 1229363-11-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

FFAR2

7.9 (pEC₅₀, 人源)

FFAR2

7.3 (pEC₅₀, 鼠源)

All Free Fatty Acid Receptor Isoforms :

In Vitro

FFA2 agonist-2 (compound 8) acts as a potent agonist at both hFFA2 and mFFA2 receptors in CHO cells, with a pEC₅₀ of 7.9 (hFFA2) and 7.3 (mFFA2), and binds to hFFA2 with a pK_i of 6.7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_unbound	T_1/2	F
Rat^[1]	1 mg/kg	i.v.	2800 mL/min/kg	590 min	/
Rat^[1]	3 mg/kg	p.o.	/	/	47 %

In Vivo

FFA2 agonist-2 (compound 8) (50 mg/kg; p.o.; single dose) does not produce a statistically significant reduction in peak blood glucose levels in a mouse OGTT model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1229363-11-4
Molecular Weight 475.39
Formula C₂₃H₂₀Cl₂N₂O₃S
SMILES

OC(C[C@@H](CC1=CC=CC=C1)C(N(C2CC2)C3=NC(C4=C(C=CC(Cl)=C4)Cl)=CS3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hoveyda HR, et al. N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem. 2018;26(18):5169-5180. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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