FFA2 agonist-2 

FFA2 agonist-2 is a potent agonist of the FFA2 (GPR43) receptor, with a pEC₅₀ of 7.9 for human FFA2, and a pEC₅₀ of 7.3 for murine FFA2. FFA2 agonist-2 acts as an orthosteric agonist and shows no obvious cross‑activity against FFA1, FFA3 and FFA4. FFA2 agonist-2 can be used for FFA2 receptor research in type 2 diabetes and metabolic disorders^[1].

FFA2 agonist-2 (compound 8) acts as a potent agonist at both hFFA2 and mFFA2 receptors in CHO cells, with a pEC₅₀ of 7.9 (hFFA2) and 7.3 (mFFA2), and binds to hFFA2 with a pK_i of 6.7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FFA2 agonist-2 (compound 8) (50 mg/kg; p.o.; single dose) does not produce a statistically significant reduction in peak blood glucose levels in a mouse OGTT model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

475.39

C₂₃H₂₀Cl₂N₂O₃S

1229363-11-4

OC(C[C@@H](CC1=CC=CC=C1)C(N(C2CC2)C3=NC(C4=C(C=CC(Cl)=C4)Cl)=CS3)=O)=O

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• [1]. Hoveyda HR, et al. N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model. Bioorg Med Chem. 2018;26(18):5169-5180.